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pubmed-article:9682356pubmed:abstractTextAnnual influenza vaccine is recommended for persons with HIV infection. Recent reports indicate that immunizations may increase HIV replication in infected individuals. Forty-seven HIV-infected patients were randomized to influenza vaccine or saline placebo using a double blind study design. One month after vaccination, plasma HIV-1 RNA increased in the vaccinated but not placebo group (p = 0.029). At 3 months, CD4% dropped an average of 1.6 points in the vaccinated group compared to an increase of 0.1 points in the placebo group (p = 0.039). Patients on stable antiretroviral regimens had CD4% drop an average of 2.3 points in the vaccinated group at 3 months versus 0.1 points in the placebo group (p = 0.015). It is concluded that HIV-infected patients are at risk for increased HIV replication and decreases in CD4% following influenza vaccination. Since influenza has not been associated with significant morbidity in this population, further study of routine influenza vaccination for HIV-infected patients is warranted.lld:pubmed
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pubmed-article:9682356pubmed:dateRevised2005-11-22lld:pubmed
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pubmed-article:9682356pubmed:articleTitleEffects of influenza vaccination in HIV-infected adults: a double-blind, placebo-controlled trial.lld:pubmed
pubmed-article:9682356pubmed:affiliationDepartment of Internal Medicine (Infectious Diseases Division), Naval Medical Centre, San Diego, CA 92134-5000, USA.lld:pubmed
pubmed-article:9682356pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9682356pubmed:publicationTypeClinical Triallld:pubmed
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