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rdf:type |
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lifeskim:mentions |
umls-concept:C0001038,
umls-concept:C0028623,
umls-concept:C0040649,
umls-concept:C0449432,
umls-concept:C1167139,
umls-concept:C1179435,
umls-concept:C1336572,
umls-concept:C1514873,
umls-concept:C1515021,
umls-concept:C1524073,
umls-concept:C1546857,
umls-concept:C1548799,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1705248,
umls-concept:C1948023
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pubmed:issue |
1
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pubmed:dateCreated |
1998-8-11
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pubmed:abstractText |
A number of transcriptional coactivator proteins have been identified as histone acetyltransferase (HAT) proteins, providing a direct molecular basis for the coupling of histone acetylation and transcriptional activation. The yeast Spt-Ada-Gcn5-acetyltransferase (SAGA) complex requires the coactivator protein Gcn5 for HAT activity. Identification of protein subunits by mass spectrometry and immunoblotting revealed that the TATA binding protein-associated factors (TAF(II)s) TAF(II)90, -68/61, -60, -25/23, and -20/17 are integral components of this complex. In addition, TAF(II)68 was required for both SAGA-dependent nucleosomal HAT activity and transcriptional activation from chromatin templates in vitro. These results illustrate a role for certain TAF(II) proteins in the regulation of gene expression at the level of chromatin modification that is distinct from the TFIID complex and TAF(II)145.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GCN5 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/NGG1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleosomes,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/SPT3 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TATA-Binding Protein Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/TATA-Box Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor TFIID,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9674426-Acetyltransferases,
pubmed-meshheading:9674426-DNA-Binding Proteins,
pubmed-meshheading:9674426-Fungal Proteins,
pubmed-meshheading:9674426-Histone Acetyltransferases,
pubmed-meshheading:9674426-Histones,
pubmed-meshheading:9674426-Nucleosomes,
pubmed-meshheading:9674426-Protein Kinases,
pubmed-meshheading:9674426-Saccharomyces cerevisiae,
pubmed-meshheading:9674426-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:9674426-TATA-Binding Protein Associated Factors,
pubmed-meshheading:9674426-TATA-Box Binding Protein,
pubmed-meshheading:9674426-Transcription, Genetic,
pubmed-meshheading:9674426-Transcription Factor TFIID,
pubmed-meshheading:9674426-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802-4500, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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