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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-9-24
|
| pubmed:abstractText |
A three-dimensional finite element analysis was used to quantify the patterns of mechanical stresses within the rabbit distal femur growth plate, and test the hypothesis that these patterns are correlated to measured patterns of bone growth rates. This investigation of normal development is the first step toward improving our understanding of the role of mechanical factors in bone growth abnormalities. Rabbits from five age groups ranging from 1 to 42 days were evaluated, and four different loading conditions were analyzed, representing specific time points in the normal gait cycle. Finite element models generated directly from micro-computed tomography images of the distal femurs identified regional variations in stress and strain parameters, similar to the variations in bone growth rates measured using fluorochrome labeling. A linear regression analysis supports the hypothesis that high compressive stresses are correlated with lower bone growth rates. However, for the loading conditions considered in this study, the variations in mechanical stress and strain parameters explain no more than 15% of the overall variations in bone growth rates. The greatest variations in both growth rates and mechanical stresses were present in the anterior frontal plane from the 42 day age group, in which correlations between reduced bone growth rates and compressive stresses were much stronger (r2 up to 0.80).
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-9290
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
327-35
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading | |
| pubmed:year |
1998
|
| pubmed:articleTitle |
Are regional variations in bone growth related to mechanical stress and strain parameters?
|
| pubmed:affiliation |
Orthopaedic Research Laboratories, Orthopaedic Surgery, The University of Michigan, Ann Arbor 48109-0486, USA. amlerner@me.rochester.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|