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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1998-8-20
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pubmed:abstractText |
To identify sites of action of volatile anesthetics, we are studying genes in a functional pathway that controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. The unc-1 gene occupies a central position in this pathway. Different alleles of unc-1 have unique effects on sensitivity to the different volatile anesthetics. UNC-1 shows extensive homology to human stomatin, an integral membrane protein thought to regulate an associated ion channel. We postulate that UNC-1 has a direct effect on anesthetic sensitivity in C. elegans and may represent a molecular target for volatile anesthetics.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-1321065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-1547348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-16453714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-1711812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-2058916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-2122464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-2326259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-2461560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-2900611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-3744028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-4636393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-559438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-6755267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-6782911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7227647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7477350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7509043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7694657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7937836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-7943840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8107805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8134360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8303295,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8707836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8894849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-8984009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-9088993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-9210792,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9671752-9375655
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8761-6
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:9671752-Amino Acid Sequence,
pubmed-meshheading:9671752-Anesthetics, Inhalation,
pubmed-meshheading:9671752-Animals,
pubmed-meshheading:9671752-Base Sequence,
pubmed-meshheading:9671752-Blood Proteins,
pubmed-meshheading:9671752-Caenorhabditis elegans,
pubmed-meshheading:9671752-Caenorhabditis elegans Proteins,
pubmed-meshheading:9671752-DNA Primers,
pubmed-meshheading:9671752-Humans,
pubmed-meshheading:9671752-Membrane Proteins,
pubmed-meshheading:9671752-Molecular Sequence Data,
pubmed-meshheading:9671752-Sequence Homology, Amino Acid
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pubmed:year |
1998
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pubmed:articleTitle |
Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans.
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pubmed:affiliation |
Departments of Anesthesiology and Genetics, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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