Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-21
pubmed:abstractText
Activation of protein-encoding genes involves recruitment of an RNA polymerase II holoenzyme to promoters. Since the Srb4 subunit of the holoenzyme is essential for expression of most class II genes and is a target of at least one transcriptional activator, we reasoned that suppressors of a temperature-sensitive mutation in Srb4 would identify other factors generally involved in regulation of gene expression. We report here that MED6 and SRB6, both of which encode essential components of the holoenzyme, are among the dominant suppressors and that the products of these genes interact physically with Srb4. The recessive suppressors include NCB1 (BUR6), NCB2, NOT1, NOT3, NOT5, and CAF1, which encode subunits of NC2 and the Not complex. NC2 and Not proteins are general negative regulators which interact with TATA box binding protein (TBP). Taken together, these results suggest that transcription initiation involves a dynamic balance between activation mediated by specific components of the holoenzyme and repression by multiple TBP-associated regulators.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-1312673, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-1339312, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-1628834, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-1752437, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-1934060, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2015628, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2215664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2275823, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2495535, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2692852, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-2849508, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-3047011, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-3319781, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-3323810, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-6310326, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7479959, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7553866, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7709429, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7715709, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7753848, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7774808, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7777566, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7877695, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7926748, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7935765, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7939686, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7958867, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-7958881, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8083216, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8133894, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8156588, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8187178, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8293972, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8324825, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8340360, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8428577, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8598913, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8608938, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8609996, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8649361, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8657139, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8670811, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8670902, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8702484, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8791611, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8870495, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8943321, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8946909, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8948634, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-8972183, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9016552, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9023340, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9032243, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9096360, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9121454, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9191116, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9234719, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9305922, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9343676, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9420330, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9463387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9511744, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671455-9585500
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CDC39 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Coenzymes, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/MED6 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Mediator Complex, http://linkedlifedata.com/resource/pubmed/chemical/NOT5 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/POP2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/RNA Polymerase II, http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/SRB4 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/SRB6 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/TATA-Box Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-7306
pubmed:author
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