Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-21
pubmed:abstractText
Nonmethylated CpG islands are generally located at the 5' ends of genes, but a CpG island in the mouse major histocompatibility complex class II I-Abeta gene is remote from the promoter and covers exon 2. We have found that this CpG island includes a novel intronic promoter that is active in embryonic and germ cells. The resulting transcript potentially encodes a severely truncated protein which would lack the signal peptide and external beta1 domains. The functional significance of the internal CpG island may be to facilitate gene conversion, thereby sustaining the high level of polymorphism seen at exon 2. Deletions of the I-Abeta CpG island promoter reduce transcription and frequently lead to methylation of the CpG island in a transgenic mouse assay. These and other results support the idea that all CpG islands arise at promoters that are active in early embryonic cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1093816, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1310933, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1369742, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1505946, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1546979, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1577268, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1649008, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1675156, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1693431, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1704704, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1840517, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1899139, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1909605, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1974172, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-1978723, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2041571, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2139257, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2177842, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2317863, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2385586, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2423876, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2474378, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2673924, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2880336, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-2901725, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3023820, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3428592, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3595568, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3653008, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3656447, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3785159, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3785173, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3791414, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-3921964, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-569555, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6198089, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6308570, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6326095, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6356354, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6410508, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6411350, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6571997, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6587321, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-6785347, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7504628, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7505451, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7670490, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7849743, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7916974, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7951326, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-7958895, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8090226, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8125323, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8156596, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8425217, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8462104, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8464749, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8469285, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-8797818, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-9160753, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-9184076, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-922889, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-9338788, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-9482741, http://linkedlifedata.com/resource/pubmed/commentcorrection/9671453-9545253
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4433-43
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
More...