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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1998-7-29
|
| pubmed:abstractText |
Sixty-three cases of collagenous fibroma (desmoplastic fibroblastoma) from the files of the Armed Forces Institute of Pathology were analyzed. These tumors occurred mostly in men (80%) with a median age of 50 years (range, 16 to 81 years). The lesions had a wide anatomic distribution and involved the arm (24%), shoulder girdle (19%), posterior neck or upper back (14%), feet or ankles (14%), leg (14%), hand (8%), and abdominal wall and hip (6%). The patients typically presented with a history of a painless, slowly growing mass, often of relatively long duration. The tumors ranged in size from 1 to 20 cm (median, 3.0 cm). The lesions were predominantly subcutaneous, but fascial involvement was common, and 27% of cases involved skeletal muscle. Gross examination typically showed an elongated, lobulated, or disc-shaped mass with a firm consistency and a homogeneous pearl-gray color. Histologically, the tumors often appeared well marginated on low-power examination, but most (78%) infiltrated fat or, less commonly, skeletal muscle. The lesional cells were relatively bland stellate and spindle-shaped fibroblasts separated by a collagenous or myxocollagenous matrix. Mitotic activity was absent or minimal. Some of the lesional cells had a myofibroblastic immunophenotype, as evidenced by focal reactivity for muscle-specific and alpha-smooth muscle actins. In a few cases, rare actin-positive cells were also positive for keratins. Desmin, S100 protein, and CD34 were not expressed. None of the 39 patients with follow-up (median, 11 years) developed a recurrence. Collagenous fibroma is a benign fibroblastic/myofibroblastic proliferation. The large size of some of these tumors coupled with slow growth and persistence favors a neoplastic process over a peculiar reactive proliferation. The differential diagnosis includes a variety of reactive and neoplastic fibroblastic lesions, most importantly fibromatosis and low-grade fibromyxoid sarcoma. Simple, conservative excision is the treatment of choice for collagenous fibroma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0046-8177
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
676-82
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9670823-Adolescent,
pubmed-meshheading:9670823-Adult,
pubmed-meshheading:9670823-Aged,
pubmed-meshheading:9670823-Aged, 80 and over,
pubmed-meshheading:9670823-Cytoskeletal Proteins,
pubmed-meshheading:9670823-Diagnosis, Differential,
pubmed-meshheading:9670823-Female,
pubmed-meshheading:9670823-Fibroblasts,
pubmed-meshheading:9670823-Fibroma,
pubmed-meshheading:9670823-Fibroma, Desmoplastic,
pubmed-meshheading:9670823-Fibrosarcoma,
pubmed-meshheading:9670823-Follow-Up Studies,
pubmed-meshheading:9670823-Humans,
pubmed-meshheading:9670823-Immunoenzyme Techniques,
pubmed-meshheading:9670823-Magnetic Resonance Imaging,
pubmed-meshheading:9670823-Male,
pubmed-meshheading:9670823-Middle Aged,
pubmed-meshheading:9670823-Sex Distribution,
pubmed-meshheading:9670823-Soft Tissue Neoplasms
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Collagenous fibroma (desmoplastic fibroblastoma): a clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts.
|
| pubmed:affiliation |
Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306-6000, USA.
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| pubmed:publicationType |
Journal Article
|