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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1998-8-3
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pubmed:abstractText |
Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure-bioactivity study about the cryptolepine nucleus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BiererD EDE,
pubmed-author:CooperRR,
pubmed-author:DubenkoL GLG,
pubmed-author:FortD MDM,
pubmed-author:GarofaloA WAW,
pubmed-author:GerberR ERE,
pubmed-author:ImbachP APA,
pubmed-author:LitvakJJ,
pubmed-author:LumHH,
pubmed-author:NICC,
pubmed-author:PhuanP WPW,
pubmed-author:ReavenG MGM,
pubmed-author:SloanBB,
pubmed-author:ZhangPP
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2754-64
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9667966-3T3 Cells,
pubmed-meshheading:9667966-Adipose Tissue,
pubmed-meshheading:9667966-Alkaloids,
pubmed-meshheading:9667966-Animals,
pubmed-meshheading:9667966-Biological Transport,
pubmed-meshheading:9667966-Blood Glucose,
pubmed-meshheading:9667966-Diabetes Mellitus, Experimental,
pubmed-meshheading:9667966-Glucose,
pubmed-meshheading:9667966-Hypoglycemic Agents,
pubmed-meshheading:9667966-Indole Alkaloids,
pubmed-meshheading:9667966-Indoles,
pubmed-meshheading:9667966-Mice,
pubmed-meshheading:9667966-Mice, Obese,
pubmed-meshheading:9667966-Plants, Medicinal,
pubmed-meshheading:9667966-Quinolines,
pubmed-meshheading:9667966-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.
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pubmed:affiliation |
Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA. dbierer@shaman.com
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pubmed:publicationType |
Journal Article
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