| pubmed-article:9667654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9667654 | lifeskim:mentions | umls-concept:C0079731 | lld:lifeskim |
| pubmed-article:9667654 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9667654 | lifeskim:mentions | umls-concept:C1268443 | lld:lifeskim |
| pubmed-article:9667654 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:9667654 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9667654 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9667654 | pubmed:dateCreated | 1998-7-30 | lld:pubmed |
| pubmed-article:9667654 | pubmed:abstractText | We have examined apoptosis and proliferation in lymph node cell suspensions from patients with B-cell non-Hodgkin's lymphoma using flow cytometry. A method was developed which allowed estimation of the fractions of apoptotic cells and cells in the S-phase of the cell cycle simultaneously with tumour-characteristic light chain expression. Analysis of the tumour S-phase fraction and the tumour apoptotic fraction in lymph node cell suspensions from 95 B-cell non-Hodgkin's lymphoma (NHL) patients revealed a non-normal distribution for both parameters. The median fraction of apoptotic tumour cells was 1.1% (25 percentiles 0.5%, 2.7%). In the same samples, the median fraction of apoptotic normal cells was higher than for the tumour cells (1.9%; 25 percentiles 0.7%, 4.0%; P = 0.03). The median fraction of tumour cells in S-phase was 1.4% (25 percentiles 0.8%, 4.8%), the median fraction of normal cells in S-phase was significantly lower than for the tumour cells (1.0%; 25 percentiles 0.6%, 1.9%; P = 0.004). When the number of cases was plotted against the logarithm of the S-phase fraction of the tumour cells, a distribution with two Gaussian peaks was needed to fit the data. One peak was centred around an S-phase fraction of 0.9%; the other was centred around 7%. These peaks were separated by a valley at approximately 3%, indicating that the S-phase fraction in NHL can be classified as 'low' (< 3%) or 'high' (> 3%), independent of the median S-phase fraction. The apoptotic fractions were log-normally distributed. The median apoptotic fraction was higher (1.5%) in the 'high' S-phase group than in the 'low' S-phase group (0.8%; P = 0.02). However, there was no significant correlation between the two parameters (P > 0.05). | lld:pubmed |
| pubmed-article:9667654 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9667654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9667654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9667654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9667654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9667654 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9667654 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:StokkeTT | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:KaalhusOO | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:SteenH BHB | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:SmelandE BEB | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:HolteHH | lld:pubmed |
| pubmed-article:9667654 | pubmed:author | pubmed-author:SmedshammerLL | lld:pubmed |
| pubmed-article:9667654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9667654 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:9667654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9667654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9667654 | pubmed:pagination | 1832-8 | lld:pubmed |
| pubmed-article:9667654 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
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| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
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| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
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| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
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| pubmed-article:9667654 | pubmed:meshHeading | pubmed-meshheading:9667654-... | lld:pubmed |
| pubmed-article:9667654 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9667654 | pubmed:articleTitle | Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas. | lld:pubmed |
| pubmed-article:9667654 | pubmed:affiliation | Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello. | lld:pubmed |
| pubmed-article:9667654 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9667654 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9667654 | lld:pubmed |
