Linked Life Data

9667654

Source:http://linkedlifedata.com/resource/pubmed/id/9667654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-7-30
pubmed:abstractText
We have examined apoptosis and proliferation in lymph node cell suspensions from patients with B-cell non-Hodgkin's lymphoma using flow cytometry. A method was developed which allowed estimation of the fractions of apoptotic cells and cells in the S-phase of the cell cycle simultaneously with tumour-characteristic light chain expression. Analysis of the tumour S-phase fraction and the tumour apoptotic fraction in lymph node cell suspensions from 95 B-cell non-Hodgkin's lymphoma (NHL) patients revealed a non-normal distribution for both parameters. The median fraction of apoptotic tumour cells was 1.1% (25 percentiles 0.5%, 2.7%). In the same samples, the median fraction of apoptotic normal cells was higher than for the tumour cells (1.9%; 25 percentiles 0.7%, 4.0%; P = 0.03). The median fraction of tumour cells in S-phase was 1.4% (25 percentiles 0.8%, 4.8%), the median fraction of normal cells in S-phase was significantly lower than for the tumour cells (1.0%; 25 percentiles 0.6%, 1.9%; P = 0.004). When the number of cases was plotted against the logarithm of the S-phase fraction of the tumour cells, a distribution with two Gaussian peaks was needed to fit the data. One peak was centred around an S-phase fraction of 0.9%; the other was centred around 7%. These peaks were separated by a valley at approximately 3%, indicating that the S-phase fraction in NHL can be classified as 'low' (< 3%) or 'high' (> 3%), independent of the median S-phase fraction. The apoptotic fractions were log-normally distributed. The median apoptotic fraction was higher (1.5%) in the 'high' S-phase group than in the 'low' S-phase group (0.8%; P = 0.02). However, there was no significant correlation between the two parameters (P > 0.05).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-1089792, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-1710961, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-183112, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-2013622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-2033492, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-2298418, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-2716347, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-2893097, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-415608, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-6435862, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-6824784, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-7015478, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-7681257, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-8354121, http://linkedlifedata.com/resource/pubmed/commentcorrection/9667654-8483318
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1832-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas.
pubmed:affiliation
Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't