Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-4-30
|
| pubmed:abstractText |
To substitute for exocrine pancreatic insufficiency, patients with cystic fibrosis (CF) take pancreatic enzymes (PE) originating from porcine pancreas. Five different pancreatic enzyme preparations used by our patients contained 0.5-1.4 microg selenium per g tablet. In patients taking PE in doses that were gradually increased to improve fat absorption during a 48-month period, the effects of PE dose on erythrocyte selenium-dependent glutathione peroxidase (SeGSH-Px) activities and plasma selenium concentrations were studied. At baseline, erythrocyte SeGSH-Px activities were significantly lower in patients (p=.01), while plasma selenium concentrations did not differ between patients and healthy subjects. When PE dose and, consequently, selenium intake from PE was increased, erythrocyte SeGSH-Px activities (p < .001) and plasma selenium concentrations (p=.02) increased. Changes in SeGSH-Px activities during the initial 8 months correlated with those in selenium intake from PE (r=0.67, p < .001). Plasma selenium concentrations plateaued at 12 months and erythrocyte SeGSH-Px activities did so at 36 months, when patients had reached SeGSH-Px activities similar to those of healthy subjects. At 48 months, patients took an average lipase dose of 17400 U x kg(-1) x d(-1) and selenium dose from PE of 0.53 microg x kg(-1) x d(-1). We conclude that selenium content of PE preparations has a significant effect on SeGSH-Px activity in patients with CF. This form of selenium supply needs to be taken into account when selenium supplements are given to patients with CF.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Pancreatic Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Pancreatin,
http://linkedlifedata.com/resource/pubmed/chemical/Pancrelipase,
http://linkedlifedata.com/resource/pubmed/chemical/Selenium
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0891-5849
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
242-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9667502-Administration, Oral,
pubmed-meshheading:9667502-Adolescent,
pubmed-meshheading:9667502-Adult,
pubmed-meshheading:9667502-Child,
pubmed-meshheading:9667502-Child, Preschool,
pubmed-meshheading:9667502-Cross-Sectional Studies,
pubmed-meshheading:9667502-Cystic Fibrosis,
pubmed-meshheading:9667502-Dose-Response Relationship, Drug,
pubmed-meshheading:9667502-Drug Administration Schedule,
pubmed-meshheading:9667502-Enzyme Activation,
pubmed-meshheading:9667502-Enzymes,
pubmed-meshheading:9667502-Erythrocytes,
pubmed-meshheading:9667502-Female,
pubmed-meshheading:9667502-Glutathione Peroxidase,
pubmed-meshheading:9667502-Humans,
pubmed-meshheading:9667502-Infant,
pubmed-meshheading:9667502-Lipase,
pubmed-meshheading:9667502-Longitudinal Studies,
pubmed-meshheading:9667502-Male,
pubmed-meshheading:9667502-Pancreatic Extracts,
pubmed-meshheading:9667502-Pancreatin,
pubmed-meshheading:9667502-Pancrelipase,
pubmed-meshheading:9667502-Selenium
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Effects of pancreatic enzyme preparations on erythrocyte glutathione peroxidase activities and plasma selenium concentrations in cystic fibrosis.
|
| pubmed:affiliation |
Department of Pediatrics, University of Zurich, Switzerland. brigitte.winklhoferroob@kfunigraz.ac.at
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|