Linked Life Data

9667132

Source:http://linkedlifedata.com/resource/pubmed/id/9667132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1998-8-5
pubmed:abstractText
Genetic factors play an important and probably necessary role, in the development of most forms for diabetes mellitus, but are not the sole cause of the disease. The disease seems to be caused by an interaction between polygenic inheritance and environmental factors. In type I diabetes, more than ten different genetic markers have been found to be associated with the disease. Genes in the HLA-region, on and near the insulin gene, are the most important ones. In the common form of type II diabetes, a series of candidate genes which are code for important steps in insulin secretion or action have been investigated. So far, none have been identified that contribute significantly to the development of the disease in the majority of cases. The most significant breakthrough in research in recent years has been in the study of maturity-onset diabetes of the young (MODY). Until now, mutations in five different genes, which are code for glucokinase and various transcription factors, have been found to be associated with this form of diabetes. Knowledge of the genetic heterogeneity of diabetes has led to a need for a more pathophysiologically correct classification of the disease.
pubmed:language
nor
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0029-2001
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2519-24
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[Diabetes mellitus--a complex interaction between heredity and environment].
pubmed:affiliation
Aker Diabetes Forskningssenter Aker sykehus, Oslo.
pubmed:publicationType
Journal Article, English Abstract, Review