Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-9-11
|
| pubmed:abstractText |
Ischemic stroke causes various functional deficits in the brain such as memory impairment, and clinical reports have shown that the impaired brain functions may partially recover. However, there has been no experimental model suitable for studying cellular mechanisms of functional recovery following brain ischemia. Therefore, we investigated the long-term influence of transient forebrain ischemia on excitatory synaptic transmission in the rat dentate gyrus, a brain region relatively resistant to ischemia. Fifteen minutes of transient forebrain ischemia produced no apparent histological damage in dentate granule cells, but caused a significant reduction of basal synaptic potentials evoked by perforant path stimulation. Field excitatory postsynaptic potential remained reduced for at least 1 month after ischemia, while population spike recovered to control level in 1 month. The induction of long-term potentiation was also impaired after ischemia, but it showed faster recovery than basal synaptic potentials. In conclusion, we found that synaptic transmission in the dentate gyrus of the rat is impaired following transient forebrain ischemia, but has a potential to recover. These results may provide a good model for studying the mechanisms of impairment and recovery of brain function after transient ischemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V. All rights reserved.
|
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
799
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
130-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9666102-Animals,
pubmed-meshheading:9666102-Dentate Gyrus,
pubmed-meshheading:9666102-Excitatory Postsynaptic Potentials,
pubmed-meshheading:9666102-Ischemic Attack, Transient,
pubmed-meshheading:9666102-Long-Term Potentiation,
pubmed-meshheading:9666102-Male,
pubmed-meshheading:9666102-Neuronal Plasticity,
pubmed-meshheading:9666102-Prosencephalon,
pubmed-meshheading:9666102-Rats,
pubmed-meshheading:9666102-Rats, Wistar,
pubmed-meshheading:9666102-Synapses,
pubmed-meshheading:9666102-Synaptic Transmission
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Early impairment and late recovery of synaptic transmission in the rat dentate gyrus following transient forebrain ischemia in vivo.
|
| pubmed:affiliation |
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
|
| pubmed:publicationType |
Journal Article
|