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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0007320,
umls-concept:C0015914,
umls-concept:C0037868,
umls-concept:C0043381,
umls-concept:C0085973,
umls-concept:C0439858,
umls-concept:C0449450,
umls-concept:C0681850,
umls-concept:C1140618,
umls-concept:C1521828,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
5
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pubmed:dateCreated |
1998-10-22
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pubmed:abstractText |
A case is reported in which a high fertilization rate was achieved by conventional in-vitro fertilization (IVF), using spermatozoa from an oligozoospermic man carrying a microdeletion of the long arm of the Y chromosome. The patient presented with idiopathic infertility of 10 years duration; the fertility status of his wife was completely normal. After IVF, five out of eight oocytes retrieved showed normal fertilization and four showed normal embryo cleavage. Four embryos were transferred; however, pregnancy did not result. These results demonstrate that spermatozoa from oligozoospermic patients carrying a Yq microdeletion are fully competent in achieving capacitation, acrosome reaction and fertilizing ability during IVF. Therefore, although definitive conclusions cannot be made from a single case report, we suggest that Yq microdeletion analysis should be considered in oligozoospermic patients undergoing conventional IVF.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1360-9947
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9665633-Adult,
pubmed-meshheading:9665633-Chromosome Deletion,
pubmed-meshheading:9665633-DNA Mutational Analysis,
pubmed-meshheading:9665633-Embryo Transfer,
pubmed-meshheading:9665633-Female,
pubmed-meshheading:9665633-Fertilization in Vitro,
pubmed-meshheading:9665633-Humans,
pubmed-meshheading:9665633-Male,
pubmed-meshheading:9665633-Oligospermia,
pubmed-meshheading:9665633-Sex Chromosome Aberrations,
pubmed-meshheading:9665633-Spermatozoa,
pubmed-meshheading:9665633-Y Chromosome
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pubmed:year |
1998
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pubmed:articleTitle |
Case report: high fertilization rate in conventional in-vitro fertilization utilizing spermatozoa from an oligozoospermic subject presenting microdeletions of the Y chromosome long arm.
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pubmed:affiliation |
Clinica Medica III, University of Padova, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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