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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-7-23
|
| pubmed:abstractText |
We evaluated the effects of the Zanzibar school-based deworming program on the iron status of primary school children. Parasitologic and nutritional assessments were carried out at baseline, 6 mo, and 12 mo in 4 nonprogram schools (n = 1002), 4 schools in which students received twice-yearly deworming (n = 952), and 4 schools in which students received thrice-yearly deworming (n = 970) with 500 mg generic mebendazole. Schools were randomly selected for evaluation and allocated to program groups. Relative to no treatment, thrice-yearly deworming caused significant decreases in protoporphyrin concentrations and both deworming regimens caused marginally significant increases in serum ferritin concentrations. The average annual changes in protoporphyrin concentrations were -5.9 and -23.5 micromol/mol heme in the control and thrice-yearly deworming groups, respectively (P < 0.001). The average changes in ferritin concentration were 2.8 and 4.5 microg/L, respectively (P = 0.07). Deworming had no effect on annual hemoglobin change or prevalence of anemia. However, the relative risk of severe anemia (hemoglobin < 70 g/L) was 0.77 (95% confidence limits: 0.39, 1.51) in the twice-yearly deworming group and 0.45 (0.19, 1.08) in the thrice-yearly deworming group. The effects on prevalence of high protoporphyrin values and incidence of moderate-to-severe anemia (hemoglobin < 90 g/L) were significantly greater in children with > 2000 hookworm eggs/g feces at baseline. We estimate that this deworming program prevented 1260 cases of moderate-to-severe anemia and 276 cases of severe anemia in a population of 30,000 schoolchildren in 1 y. Where hookworm is heavily endemic, deworming programs can improve iron status and prevent moderate and severe anemia, but deworming may be needed at least twice yearly.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
179-86
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9665112-Ancylostomiasis,
pubmed-meshheading:9665112-Anemia, Iron-Deficiency,
pubmed-meshheading:9665112-Animals,
pubmed-meshheading:9665112-Antinematodal Agents,
pubmed-meshheading:9665112-Ascariasis,
pubmed-meshheading:9665112-Ascaris lumbricoides,
pubmed-meshheading:9665112-Child,
pubmed-meshheading:9665112-Female,
pubmed-meshheading:9665112-Ferritins,
pubmed-meshheading:9665112-Humans,
pubmed-meshheading:9665112-Male,
pubmed-meshheading:9665112-Mebendazole,
pubmed-meshheading:9665112-Necatoriasis,
pubmed-meshheading:9665112-Nematode Infections,
pubmed-meshheading:9665112-Parasite Egg Count,
pubmed-meshheading:9665112-Protoporphyrins,
pubmed-meshheading:9665112-School Health Services,
pubmed-meshheading:9665112-Tanzania,
pubmed-meshheading:9665112-Trichuriasis
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Effects of the Zanzibar school-based deworming program on iron status of children.
|
| pubmed:affiliation |
Center for Human Nutrition, Department of International Health, The Johns Hopkins School of Public Health, Baltimore, MD 21205, USA. rstoltzf@jhsph.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|