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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-9-28
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pubmed:abstractText |
Balsalazide is a prodrug of mesalazine which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine. Balsalazide 6.75 g/day was more effective than mesalazine 2.4 g/day in at least 1 trial and as effective as sulfasalazine 3 g/day for inducing remission in patients with acute ulcerative colitis in 8- and 12-week trials. Moreover, complete symptom relief occurred more promptly with balsalizide 6.75 g/day than with mesalazine 2.4g/day. In long term studies, balsalazide 2 g/day was as effective as sulfasalazine 2 g/day and balsalazide 6 g/day was as effective as mesalazine 1.5 g/day, in maintaining remission in patients with ulcerative colitis. The tolerability profile of balsalazide is significantly better than that of sulfasalazine; 70% of sulfasalazine-intolerant patients were able to tolerate balsalazide.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminosalicylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Mesalamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylhydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/balsalazide
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0012-6667
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-9; discussion 90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9664201-Aminosalicylic Acids,
pubmed-meshheading:9664201-Anti-Ulcer Agents,
pubmed-meshheading:9664201-Colitis, Ulcerative,
pubmed-meshheading:9664201-Drug Tolerance,
pubmed-meshheading:9664201-Humans,
pubmed-meshheading:9664201-Mesalamine,
pubmed-meshheading:9664201-Phenylhydrazines
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pubmed:year |
1998
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pubmed:articleTitle |
Balsalazide.
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pubmed:affiliation |
Adis International Limited, Auckland, New Zealand.
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pubmed:publicationType |
Journal Article,
Review
|