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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-7-28
|
| pubmed:abstractText |
Three hundred seventy-nine individuals [137 non-injecting drug using (non-IDU) heterosexuals, 130 homosexual men and 112 IDU] attending the human immunodeficiency virus (HIV) testing program of a sexually transmitted disease (STD) clinic in Rome were studied to estimate the prevalence and to identify the modalities of transmission of human herpesvirus-8 (HHV-8) infection. Serological analysis was performed by using an immunofluorescence assay able to detect anti-latent and anti-lytic HHV-8 antibodies. Twelve acquired immunodeficiency syndrome (AIDS)-Kaposi's sarcoma (KS) patients and 94 blood donors were tested as reference population groups. Anti-lytic antibodies were detected in 185 (48.8%) individuals; 52 of them (13.7%) also had anti-latent antibodies. Both anti-lytic and anti-latent antibody prevalence were higher among homosexual men (66.9% and 27.7%, respectively) than among IDU (49.1% and 8.0%, respectively) and non-IDU heterosexuals (31.4% and 5.1%, respectively), and tended to increase with age. Anti-lytic HHV-8 antibodies were associated with syphilis [odds ratio (OR)=3.81] but not with hepatitis C virus (HCV) seropositivity. HIV-infected homosexual men were more likely to have HHV-8 antibodies than those who were HIV-negative. When using anti-latent antibodies the direction of the OR remained the same, although the associations did not often reach statistical significance. Among AIDS-KS patients, 83.3% had anti-lytic and 66.6% had anti-latent antibodies. Among blood donors, 28% had anti-lytic antibodies and 2 of them (2.1%) also had anti-latent antibodies. Our data indicate that HHV-8 seroprevalence increases with age and is higher among homosexual men, particularly those infected with HIV. This is consistent with sexual transmission of HHV-8 infection. In addition, the presence of HHV-8 antibodies in HIV-negative non-IDU heterosexual contacts and in healthy blood donors is consistent with the high incidence of classic KS in Italy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
77
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
361-5
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:9663596-Adolescent,
pubmed-meshheading:9663596-Adult,
pubmed-meshheading:9663596-Antibodies, Viral,
pubmed-meshheading:9663596-Female,
pubmed-meshheading:9663596-HIV Seronegativity,
pubmed-meshheading:9663596-HIV Seropositivity,
pubmed-meshheading:9663596-HIV-1,
pubmed-meshheading:9663596-Herpesviridae Infections,
pubmed-meshheading:9663596-Herpesvirus 8, Human,
pubmed-meshheading:9663596-Heterosexuality,
pubmed-meshheading:9663596-Homosexuality, Male,
pubmed-meshheading:9663596-Humans,
pubmed-meshheading:9663596-Male,
pubmed-meshheading:9663596-Prevalence,
pubmed-meshheading:9663596-Risk Factors,
pubmed-meshheading:9663596-Sarcoma, Kaposi,
pubmed-meshheading:9663596-Sexually Transmitted Diseases,
pubmed-meshheading:9663596-Substance Abuse, Intravenous,
pubmed-meshheading:9663596-Virus Latency
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections.
|
| pubmed:affiliation |
Centro Operativo AIDS-Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Rome, Italy. g.rezza@net.iss.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|