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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1998-9-28
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pubmed:abstractText |
Defensins are endogenous antimicrobial peptides. We demonstrated recently the existence of RK-1, a defensin-like peptide in rabbit kidneys. Defining the renal-defensin system is an essential step toward understanding how the kidney responds to infection. Here, using a combination of high-performance liquid chromatography, matrix-assisted laser desorption time-of-flight mass spectrometry, amino acid compositional analysis, and microsequence analysis, we show that the rabbit kidney contains a novel alpha-defensin-like peptide, RK-2. This work establishes the existence of a new subfamily of alpha-defensins in the kidney.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0196-9781
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
793-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9663443-Amino Acid Sequence,
pubmed-meshheading:9663443-Amino Acids,
pubmed-meshheading:9663443-Animals,
pubmed-meshheading:9663443-Anti-Infective Agents,
pubmed-meshheading:9663443-Blood Proteins,
pubmed-meshheading:9663443-Defensins,
pubmed-meshheading:9663443-Immunity,
pubmed-meshheading:9663443-Kidney,
pubmed-meshheading:9663443-Molecular Sequence Data,
pubmed-meshheading:9663443-Rabbits,
pubmed-meshheading:9663443-Spectrometry, Mass, Matrix-Assisted Laser...
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pubmed:year |
1998
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pubmed:articleTitle |
RK-2: a novel rabbit kidney defensin and its implications for renal host defense.
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pubmed:affiliation |
Royal Victoria Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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