| pubmed-article:9662252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0016360 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0040085 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9662252 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9662252 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9662252 | pubmed:dateCreated | 1998-7-20 | lld:pubmed |
| pubmed-article:9662252 | pubmed:abstractText | Six human cancer cell lines exhibiting a large range of sensitivity to 5-fluorouracil (5-FU) were evaluated for thymidylate synthase (TS) and p53 gene expression, TS and dihydropyrimidine dehydrogenase (DPD) activity, as well as cell cycle parameters, S-phase fraction (SPF), bromodeoxyuridine labelling index (LI) and S-phase duration (SPD). All these parameters were investigated for 7 days in asynchronously growing cell populations and compared with the cell sensitivity to 5-FU. No significant correlation was found between S-phase parameters and TS gene expression and/or activity. TS activity was higher in proliferating cells; however, it was not significantly higher in rapidly growing cell lines with short SPD. Neither TS gene expression nor activity was found to correlate with 5-FU sensitivity. On the another hand, a statistically significant correlation (P < 0.0001) was observed between LI and SPD and 5-FU sensitivity. The present results suggest that cell cycle parameters such as SPD and/or LI could be better parameters for 5-FU sensitivity prediction than TS gene expression and/or activity. This could be especially informative in cases of concomitant radio-chemotherapy as S-phase parameters are already proposed for hyperfractionated radiotherapy planning. | lld:pubmed |
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| pubmed-article:9662252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9662252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9662252 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9662252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9662252 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9662252 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:BeyPP | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:MarchalSS | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:MilanoGG | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:EtienneM CMC | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:MerlinJ LJL | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:Barberi-Heyob... | lld:pubmed |
| pubmed-article:9662252 | pubmed:author | pubmed-author:MirjoletJ FJF | lld:pubmed |
| pubmed-article:9662252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9662252 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:9662252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9662252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9662252 | pubmed:pagination | 62-8 | lld:pubmed |
| pubmed-article:9662252 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9662252 | pubmed:meshHeading | pubmed-meshheading:9662252-... | lld:pubmed |
| pubmed-article:9662252 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9662252 | pubmed:articleTitle | Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity. | lld:pubmed |
| pubmed-article:9662252 | pubmed:affiliation | Centre Alexis Vautrin, Laboratoire de Recherche en Oncologie, Vandoeuvre-les-Nancy, France. | lld:pubmed |
| pubmed-article:9662252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9662252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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