| pubmed-article:9660935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9660935 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:9660935 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9660935 | pubmed:dateCreated | 1998-7-28 | lld:pubmed |
| pubmed-article:9660935 | pubmed:abstractText | We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo. | lld:pubmed |
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| pubmed-article:9660935 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9660935 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9660935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9660935 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9660935 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:LinC HCH | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:ManiatisTT | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:HowleyP MPM | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:WatheletM GMG | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:ParekhB SBS | lld:pubmed |
| pubmed-article:9660935 | pubmed:author | pubmed-author:RoyalW AWA | lld:pubmed |
| pubmed-article:9660935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9660935 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:9660935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9660935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9660935 | pubmed:pagination | 507-18 | lld:pubmed |
| pubmed-article:9660935 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9660935 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9660935 | pubmed:articleTitle | Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. | lld:pubmed |
| pubmed-article:9660935 | pubmed:affiliation | Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. | lld:pubmed |
| pubmed-article:9660935 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9660935 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9660935 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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