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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1998-9-17
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pubmed:abstractText |
The efficacy of an Indian preparation of immune serum globulins (ISG) was evaluated among pregnant women during an epidemic of hepatitis E in Karad, Western India from January to March 1993. Ten of 55 women receiving ISG developed immunoglobulin M (IgM) antibodies to hepatitis E virus (anti-HEV) during the 1 month of follow-up compared with 18 out of 53 control subjects. Although the total number of recent HEV infections was significantly less in the ISG-treated group, no significant difference could be shown in the proportion of clinical hepatitis E cases because of the very small numbers of patients who developed clinical disease. The observed marginal beneficial effect of ISG might be the result of a low immunoglobulin G (IgG) anti-HEV IgG titre (1:500) of the ISG preparation used. Preparation and testing of high-titred ISG should be a high priority for protecting pregnant women during epidemics of hepatitis E.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1352-0504
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-204
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9658374-Disease Outbreaks,
pubmed-meshheading:9658374-Female,
pubmed-meshheading:9658374-Hepatitis Antibodies,
pubmed-meshheading:9658374-Hepatitis E,
pubmed-meshheading:9658374-Hepatitis E virus,
pubmed-meshheading:9658374-Humans,
pubmed-meshheading:9658374-Immune Sera,
pubmed-meshheading:9658374-Immunoglobulins,
pubmed-meshheading:9658374-Pregnancy,
pubmed-meshheading:9658374-Pregnancy Complications, Infectious
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pubmed:year |
1998
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pubmed:articleTitle |
Role of immune serum globulins in pregnant women during an epidemic of hepatitis E.
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pubmed:affiliation |
National Institute of Virology, Pune, India.
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pubmed:publicationType |
Journal Article
|