Linked Life Data

9658363

Source:http://linkedlifedata.com/resource/pubmed/id/9658363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-10-6
pubmed:abstractText
HIV infection is associated with hypercortisolemia. Since glucocorticoids have been shown to stimulate the replication of several viruses, we examined the effects of cortisol on HIV replication in cultured monocyte-derived macrophages (MDM), a cell type that has been proposed to serve as a viral reservoir. Our data revealed that physiological concentrations of cortisol upregulate viral replication in MDM. Because the dose-response curve for cortisol on HIV replication in vivo is not known, the clinical relevance of these findings remain uncertain. Clinical studies are needed to characterize the effects of corticosteroid therapy on viral burden in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1055-3290
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-83
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Cortisol upregulates HIV p24 antigen production in cultured human monocyte-derived macrophages.
pubmed:affiliation
Department of Adult Health Nursing, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
pubmed:publicationType
Journal Article