Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1998-10-6
pubmed:abstractText
This study has found that mitochondrial NADH-CoQ1 reductase (complex I) activity is significantly lower in C57 mice astrocytes compared with Wistar and Sprague-Dawley rat astrocytes, and a human astrocytoma cell line. In addition, complex I activity is 4-fold greater in Sprague-Dawley neurones when compared to Wistar or C57 neurones. These findings have important implications for mitochondrial studies involving rodent or human cell line systems, and in particular, indicate the importance of choosing an appropriate model when investigating the mitochondrial respiratory chain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Citrate (si)-Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group, http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex I, http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex II, http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex III, http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes, http://linkedlifedata.com/resource/pubmed/chemical/NAD(P)H Dehydrogenase (Quinone), http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, http://linkedlifedata.com/resource/pubmed/chemical/Succinate Dehydrogenase
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
247
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9655628-Animals, pubmed-meshheading:9655628-Astrocytes, pubmed-meshheading:9655628-Astrocytoma, pubmed-meshheading:9655628-Brain Neoplasms, pubmed-meshheading:9655628-Cells, Cultured, pubmed-meshheading:9655628-Citrate (si)-Synthase, pubmed-meshheading:9655628-Cytochrome c Group, pubmed-meshheading:9655628-Electron Transport, pubmed-meshheading:9655628-Electron Transport Complex I, pubmed-meshheading:9655628-Electron Transport Complex II, pubmed-meshheading:9655628-Electron Transport Complex III, pubmed-meshheading:9655628-Humans, pubmed-meshheading:9655628-Mice, pubmed-meshheading:9655628-Mice, Inbred C57BL, pubmed-meshheading:9655628-Mitochondria, pubmed-meshheading:9655628-Multienzyme Complexes, pubmed-meshheading:9655628-NAD(P)H Dehydrogenase (Quinone), pubmed-meshheading:9655628-NADH, NADPH Oxidoreductases, pubmed-meshheading:9655628-Nerve Tissue Proteins, pubmed-meshheading:9655628-Neurons, pubmed-meshheading:9655628-Oxidoreductases, pubmed-meshheading:9655628-Rats, pubmed-meshheading:9655628-Rats, Sprague-Dawley, pubmed-meshheading:9655628-Rats, Wistar, pubmed-meshheading:9655628-Species Specificity, pubmed-meshheading:9655628-Succinate Dehydrogenase, pubmed-meshheading:9655628-Tumor Cells, Cultured
pubmed:year
1998
pubmed:articleTitle
Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line.
pubmed:affiliation
Department of Neurochemistry, Institute of Neurology, London, UK. v.stewart@ion.ucl.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't