rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2-3
|
pubmed:dateCreated |
1998-10-6
|
pubmed:abstractText |
Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [3H]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the I2-imidazoline receptor located in mitochondria of glial (astrocyte) cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0304-3940
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
247
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
95-8
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9655601-Aged,
pubmed-meshheading:9655601-Aged, 80 and over,
pubmed-meshheading:9655601-Alzheimer Disease,
pubmed-meshheading:9655601-Astrocytes,
pubmed-meshheading:9655601-Atrophy,
pubmed-meshheading:9655601-Biological Markers,
pubmed-meshheading:9655601-Female,
pubmed-meshheading:9655601-Frontal Lobe,
pubmed-meshheading:9655601-Glial Fibrillary Acidic Protein,
pubmed-meshheading:9655601-Humans,
pubmed-meshheading:9655601-Imidazoline Receptors,
pubmed-meshheading:9655601-Male,
pubmed-meshheading:9655601-Nerve Tissue Proteins,
pubmed-meshheading:9655601-Receptors, Adrenergic, alpha,
pubmed-meshheading:9655601-Receptors, Drug
|
pubmed:year |
1998
|
pubmed:articleTitle |
Imidazoline receptor proteins in brains of patients with Alzheimer's disease.
|
pubmed:affiliation |
Department of Psychiatry, Faculty of Medicine, University of Geneva, H.U.G., Chêne-Bourg, Switzerland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|