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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-7-16
|
| pubmed:abstractText |
Human papillomaviruses (HPV) have been implicated in the etiology of anogenital squamous epithelial tumors. Of the 65 HPV strains, subtypes HPV-16 and HPV-18 frequently are associated with malignant conditions and are capable of transforming keratinocytes in vitro. However, additional cellular changes are necessary to confer tumorigenicity to HPV-infected cells. Secondary events implicated in the progression to malignancy include loss of tumor suppressor genes such as p53 and/or activation of cellular oncogenes such as c-rasHa.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0008-543X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
122-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9655301-Carcinoma, Squamous Cell,
pubmed-meshheading:9655301-DNA, Viral,
pubmed-meshheading:9655301-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9655301-Genes, p53,
pubmed-meshheading:9655301-Genes, ras,
pubmed-meshheading:9655301-Humans,
pubmed-meshheading:9655301-Keratins,
pubmed-meshheading:9655301-Male,
pubmed-meshheading:9655301-Middle Aged,
pubmed-meshheading:9655301-Mutation,
pubmed-meshheading:9655301-Papillomaviridae,
pubmed-meshheading:9655301-Penile Neoplasms
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
A c-rasHa mutation in the metastasis of a human papillomavirus (HPV)-18 positive penile squamous cell carcinoma suggests a cooperative effect between HPV-18 and c-rasHa activation in malignant progression.
|
| pubmed:affiliation |
Department of Dermatology, Baylor College of Medicine, Houston, Texas 77030, USA.
|
| pubmed:publicationType |
Journal Article
|