Linked Life Data

9654678

Source:http://linkedlifedata.com/resource/pubmed/id/9654678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-9-24
pubmed:abstractText
Comparison of the herpes simplex virus type 1 (HSV-1) DNA sequence with that of other alpha, beta and gamma-herpesviruses, allied with molecular genetic studies have greatly increased understanding of the HSV genome and the functions encoded by individual virus genes and has facilitated the development of rational antiviral strategies. Here we review the coding content of the HSV-1 genome and identify: genes encoding structural components of the capsid, tegument or envelope; genes whose products are essential for growth in tissue culture; and genes that are conserved between members of the alpha, beta and gamma-herpesvirinae. The HSV lifecycle and the main regulation cascade is discussed and genes that present targets for antiviral intervention identified. The protein content of the infectious virion particle is reviewed and compared with that of two additional non-infectious HSV-related particles species (L-particles and pre-DNA replication particles (PREPs)). The potential of HSV-1 L particles and PREP particles as DNA-free HSV-1 vaccine candidates and the desirability of deleting specific gene products from live HSV vaccines is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-8569
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-51
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
HSV molecular biology: general aspects of herpes simplex virus molecular biology.
pubmed:affiliation
Division of Virology, University of Glasgow, Scotland.
pubmed:publicationType
Journal Article, Review