Linked Life Data

9654009

Source:http://linkedlifedata.com/resource/pubmed/id/9654009

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-9-29
pubmed:abstractText
A classical model to study pattern formation is provided by the epidermal sensory organs (bristles and other sensilla) that cover the body of Drosophila. Many of these sensory organs (SOs) arise in very constant positions. How are these positions specified? To a large extent, they are defined by the highly resolved sites of expression of the proneural genes of the achaete-scute complex (AS-C). These genes, which confer to cells the capacity to become SO precursors, attain their resolved patterns of expression by means of many position-specific enhancers located within the non-transcribed AS-C DNA. Each enhancer drives expression at one or very few sites. Evidence is growing that the enhancers interact with combinations of activators and repressors (prepattern) distributed in partially overlapping domains which are larger than the AS-C expressing sites. AS-C transcription is activated only at sites with appropriate combinations of factors. Thus, the AS-C integrates the positional information embodied in the relatively broad distributions of prepattern factors and creates a sharper and topographically more precise pattern.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
The achaete-scute complex as an integrating device.
pubmed:affiliation
Centro de Biología Molecular Severo Ochoa, CSIC and Universidad Autónoma de Madrid, Spain. jmodol@mvax.cbm.uam.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't