Linked Life Data

965390

Source:http://linkedlifedata.com/resource/pubmed/id/965390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1976-11-21
pubmed:abstractText
Transformed mouse fibroblasts, in which [3H]arachidonic acid was incorporated in the cellular lipids, released radioactive materials into the medium when stimulated by bradykinin and thrombin. Most of this released radioactivity was found in the landins; the remainder was present in the arachidonic acid fraction. When the cells stimulated by serum or when they were mechanically manipulated, not only prostaglandins but also high levels of arachidonic acid were released. Anti-inflammatory steroids, which decrease the availability of arachidonic acid, inhibited the stimulated release of prostaglandins caused by the vasoactive agents, suggesting that bradykinin and thrombin stimulated prostaglandin synthesis by increasing deacylation of the phospholipids. The efficiency of the conversion of the released arachidonic acid into prostaglandins appears to reflect the cellular proximity of the phospholipid deacylating activity and prostaglandin synthesizing system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
251
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5814-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5-5 fibroblasts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.