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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025267,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0086418,
umls-concept:C0205250,
umls-concept:C0239307,
umls-concept:C0553695,
umls-concept:C1171362,
umls-concept:C1421577,
umls-concept:C1513822,
umls-concept:C1515670,
umls-concept:C1520381,
umls-concept:C1880171
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pubmed:issue |
2
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pubmed:dateCreated |
1998-10-1
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pubmed:abstractText |
In the process of identification of the multiple endocrine neoplasia type 1 gene, which was recently published, we isolated a novel gene in the 11q13 region. This gene (named ZFPL1, for zinc-finger protein-like 1) is expressed strongly in the exocrine pancreas as a 1.4-kb polyadenylated RNA encoding a putative protein of 310 amino acids. A mouse EST contig predicts an equally sized murine protein with 91% amino acid sequence identity to the human protein. No significant homology with known proteins could be found through database screening. However, zinc-finger-like domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation. This notion is supported by the presence of a putative bipartite nuclear localization signal. This paper presents the full-length cDNA sequence for this gene, its genomic structure and chromosomal orientation, and expression studies by Northern blot hybridization and RNA in situ hybridization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0888-7543
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pubmed:author |
pubmed-author:BassettJ HJH,
pubmed-author:CalenderAA,
pubmed-author:De WitM JMJ,
pubmed-author:FarneboFF,
pubmed-author:ForbesS ASA,
pubmed-author:GaudrayPP,
pubmed-author:HöppenerJ WJW,
pubmed-author:KanNN,
pubmed-author:KhodaeiSS,
pubmed-author:LarssonCC,
pubmed-author:LemmensII,
pubmed-author:LipsC JCJ,
pubmed-author:PannettA AAA,
pubmed-author:ParenteFF,
pubmed-author:QuinceyDD,
pubmed-author:RoijersJ FJF,
pubmed-author:Simarro-DoortenA YAY,
pubmed-author:TeiMM,
pubmed-author:ThakkerR VRV,
pubmed-author:Van de VenW JWJ,
pubmed-author:WeberGG,
pubmed-author:ZhangC XCX,
pubmed-author:van HerrewaardenH MHM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9653652-Amino Acid Sequence,
pubmed-meshheading:9653652-Animals,
pubmed-meshheading:9653652-Base Sequence,
pubmed-meshheading:9653652-Blotting, Northern,
pubmed-meshheading:9653652-Blotting, Southern,
pubmed-meshheading:9653652-Chromosome Mapping,
pubmed-meshheading:9653652-Chromosomes, Human, Pair 11,
pubmed-meshheading:9653652-DNA, Complementary,
pubmed-meshheading:9653652-DNA-Binding Proteins,
pubmed-meshheading:9653652-Exons,
pubmed-meshheading:9653652-Gene Expression,
pubmed-meshheading:9653652-Humans,
pubmed-meshheading:9653652-In Situ Hybridization,
pubmed-meshheading:9653652-Introns,
pubmed-meshheading:9653652-Leucine Zippers,
pubmed-meshheading:9653652-Mice,
pubmed-meshheading:9653652-Molecular Sequence Data,
pubmed-meshheading:9653652-Pancreas,
pubmed-meshheading:9653652-RNA,
pubmed-meshheading:9653652-Rats,
pubmed-meshheading:9653652-Sequence Analysis, DNA,
pubmed-meshheading:9653652-Zinc Fingers
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pubmed:year |
1998
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pubmed:articleTitle |
A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1.
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pubmed:affiliation |
Department of Internal Medicine, Utrecht University Hospital, The Netherlands. j.w.m.hoeppener@lab.azu.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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