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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-9-17
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pubmed:abstractText |
Although synthetic nonviral vectors hold promise for the delivery of plasmid DNA, their gene-transfer efficiencies are far from matching those of viruses. To systematically investigate the structure-activity relationship of cationic lipids, a small library of cationic lipid-peptoid conjugates (lipitoids) was synthesized. The compounds were evaluated for their ability to form complexes with plasmid DNA and to mediate DNA transfer in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-54
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pubmed:dateRevised |
2006-5-1
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pubmed:meshHeading |
pubmed-meshheading:9653553-3T3 Cells,
pubmed-meshheading:9653553-Animals,
pubmed-meshheading:9653553-COS Cells,
pubmed-meshheading:9653553-Cations,
pubmed-meshheading:9653553-DNA,
pubmed-meshheading:9653553-Deoxyribonuclease I,
pubmed-meshheading:9653553-Drug Carriers,
pubmed-meshheading:9653553-Electrophoresis, Agar Gel,
pubmed-meshheading:9653553-Fibrosarcoma,
pubmed-meshheading:9653553-Humans,
pubmed-meshheading:9653553-Macromolecular Substances,
pubmed-meshheading:9653553-Mice,
pubmed-meshheading:9653553-Microscopy, Electron,
pubmed-meshheading:9653553-Particle Size,
pubmed-meshheading:9653553-Peptoids,
pubmed-meshheading:9653553-Phospholipids,
pubmed-meshheading:9653553-Plasmids,
pubmed-meshheading:9653553-Surface Properties,
pubmed-meshheading:9653553-Transfection
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pubmed:year |
1998
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pubmed:articleTitle |
Lipitoids--novel cationic lipids for cellular delivery of plasmid DNA in vitro.
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pubmed:affiliation |
Chiron Technologies, Chiron Corporation, Emeryville, CA 94608, USA.
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pubmed:publicationType |
Journal Article
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