|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1998-7-27
|
|
pubmed:abstractText |
The frequencies of HLA class I antigens and class II haplotypes were compared in subjects with previous (polymerase chain reaction [PCR]-negative) or with persistent (PCR-positive) hepatitis C virus (HCV) infection and in HCV patients with mild versus severe histologic activity scores on liver biopsy. The DRB1*11 allele group was found in 11 (31.4%) of 35 subjects with previous infection and in 11 (8.2%) of 135 subjects with persistent infection (P < .001). The DQB1*0301 allele was found in 18 (51.4%) of 35 subjects with previous infection and in 33 (24.4%) of 135 patients with persistent infection (P < .002). Both observations remained significant after correction for multiple testing. No significant association was shown between severity of disease and any HLA class I or II type. Thus, the HLA class II alleles DRB1*11 and DQB1*0301 are associated with clearance of circulating HCV.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
178
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
39-44
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9652421-Adult,
pubmed-meshheading:9652421-Alleles,
pubmed-meshheading:9652421-Female,
pubmed-meshheading:9652421-Genes, MHC Class II,
pubmed-meshheading:9652421-HLA-DQ Antigens,
pubmed-meshheading:9652421-HLA-DQ beta-Chains,
pubmed-meshheading:9652421-HLA-DR Antigens,
pubmed-meshheading:9652421-HLA-DRB1 Chains,
pubmed-meshheading:9652421-Hepacivirus,
pubmed-meshheading:9652421-Hepatitis C,
pubmed-meshheading:9652421-Hepatitis C Antibodies,
pubmed-meshheading:9652421-Histocompatibility Antigens Class I,
pubmed-meshheading:9652421-Histocompatibility Antigens Class II,
pubmed-meshheading:9652421-Histocompatibility Testing,
pubmed-meshheading:9652421-Humans,
pubmed-meshheading:9652421-Male,
pubmed-meshheading:9652421-Viremia
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Association between MHC class II alleles and clearance of circulating hepatitis C virus. Members of the Trent Hepatitis C Virus Study Group.
|
|
pubmed:affiliation |
Department of Microbiology and Infectious Diseases, City and University Hospitals, Nottingham, United Kingdom.
|
|
pubmed:publicationType |
Journal Article
|
