Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1998-10-26
pubmed:abstractText
The aims of this study were (a) to compare in the rat isolated perfused lung preparation, the effects of isoprenaline and of three beta3-adrenoceptors agonists, SR 59104A, (N-[(6hydroxy-1,2,3,4-tetrahydronaphtalen-(2 R)-2yl)methyl]-(2R)-2-hydroxy-2-(3-chlorophenyl)ethanamine hydrochloride), SR 59119A (N[(7-methoxy-1,2,3,4-tetrahydronaphtalen-(2R)-2yl)methyl]-( 2R)-2-hydroxy-2-(3-chlorophenyl)ethanamine hydrochloride) and SR 58611A (ethyl¿(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7, 8-tetrahydronaphtalen-2-yloxy¿acetate hydrochloride) on hypoxia-induced pulmonary vasoconstriction, and (b) to investigate the potential existence of atypical beta-adrenoceptors in these effects. Propranolol (0.1 microM) was used to antagonize beta1- and beta2-adrenoceptors whereas SR 59230A, 3-(2-ethylphenoxy)-1-[(1S)-1,2,3,4-tetrahydronapht-1-ylam ino]-(2S)-2-propanol oxalate) (0.3 microM) was used to block beta3-adrenoceptors. Isoprenaline and the three beta3-adrenoceptors agonists caused concentration-dependent relaxations during the pulmonary pressure response. Propranolol and SR 59230A inhibited the relaxant effects of isoprenaline. SR 59230A but not propranolol inhibited those of SR 59104A. Finally, propranolol and SR 59230A failed to oppose SR 59119A- and SR 58611A-induced relaxant effects. In concentrations > or = 1 microM, SR 59230A caused per se a relaxation of the hypoxic vasoconstricted lung. These results suggest the existence of atypical beta-adrenoceptors in the rat pulmonary vessels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3-(2-ethylphenoxy)-1-(1,2,3,4-tetrah..., http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines, http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol, http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines, http://linkedlifedata.com/resource/pubmed/chemical/Propranolol, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3, http://linkedlifedata.com/resource/pubmed/chemical/SR 58611A, http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
348
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:9652337-Adrenergic beta-Agonists, pubmed-meshheading:9652337-Adrenergic beta-Antagonists, pubmed-meshheading:9652337-Animals, pubmed-meshheading:9652337-Anoxia, pubmed-meshheading:9652337-Dose-Response Relationship, Drug, pubmed-meshheading:9652337-Ethanolamines, pubmed-meshheading:9652337-Isoproterenol, pubmed-meshheading:9652337-Lung, pubmed-meshheading:9652337-Male, pubmed-meshheading:9652337-Propanolamines, pubmed-meshheading:9652337-Propranolol, pubmed-meshheading:9652337-Pulmonary Circulation, pubmed-meshheading:9652337-Rats, pubmed-meshheading:9652337-Rats, Wistar, pubmed-meshheading:9652337-Receptors, Adrenergic, beta, pubmed-meshheading:9652337-Receptors, Adrenergic, beta-3, pubmed-meshheading:9652337-Tetrahydronaphthalenes, pubmed-meshheading:9652337-Vasoconstriction, pubmed-meshheading:9652337-Vasodilation
pubmed:year
1998
pubmed:articleTitle
Influence of beta-adrenoceptor agonists on the pulmonary circulation. Effects of a beta3-adrenoceptor antagonist, SR 59230A.
pubmed:affiliation
Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaires Expérimentales, Faculté de Médecine, Dijon, France.
pubmed:publicationType
Journal Article, Comparative Study