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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5373
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pubmed:dateCreated |
1998-7-23
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pubmed:abstractText |
Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-9
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9651253-Adoptive Transfer,
pubmed-meshheading:9651253-Animals,
pubmed-meshheading:9651253-Antibody Formation,
pubmed-meshheading:9651253-Antigen Presentation,
pubmed-meshheading:9651253-B-Lymphocytes,
pubmed-meshheading:9651253-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9651253-CD40 Ligand,
pubmed-meshheading:9651253-Cell Movement,
pubmed-meshheading:9651253-Dendritic Cells,
pubmed-meshheading:9651253-Germinal Center,
pubmed-meshheading:9651253-Immunization,
pubmed-meshheading:9651253-Immunoglobulin M,
pubmed-meshheading:9651253-Lymph Nodes,
pubmed-meshheading:9651253-Lymphocyte Activation,
pubmed-meshheading:9651253-Membrane Glycoproteins,
pubmed-meshheading:9651253-Mice,
pubmed-meshheading:9651253-Mice, Inbred BALB C,
pubmed-meshheading:9651253-Mice, Inbred C57BL,
pubmed-meshheading:9651253-Mice, Transgenic,
pubmed-meshheading:9651253-Plasma Cells
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pubmed:year |
1998
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pubmed:articleTitle |
Visualization of specific B and T lymphocyte interactions in the lymph node.
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pubmed:affiliation |
University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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