| pubmed-article:9650944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:9650944 | lifeskim:mentions | umls-concept:C0483368 | lld:lifeskim |
| pubmed-article:9650944 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9650944 | pubmed:dateCreated | 1998-9-28 | lld:pubmed |
| pubmed-article:9650944 | pubmed:abstractText | Serum samples from patients with confirmed human granulocytic ehrlichiosis (HGE) were tested for cytoplasmic, nuclear, and platelet autoantibodies and rheumatoid factor. The indirect fluorescence antinuclear antibody test on Hep-2 cells demonstrated antinuclear titers of > or = 40 and > or = 160 in 44 and 10%, respectively, of serum samples from HGE patients. Two patients (4%) had anticytoplasmic (mitochondrial and spindle apparatus) antibodies with a titer of 80 and two patients (4%) had anticytoplasmic (mitochondrial) antibodies with a titer of 160 or greater. Flow cytometry was used to demonstrate antiplatelet antibodies in 80% of first serum samples from HGE patients. Rheumatoid factor was not detected. Nuclear and cytoplasmic autoantibodies are a major cause of interference when the indirect fluorescence antibody test is used to detect fluorescence of morulae in Ehrlichia-infected equine neutrophils or HL-60 promyelocytes. Antiplatelet antibodies may contribute to the profound thrombocytopenia which is a characteristic laboratory feature during the acute phase of HGE infection. Whether autoantibodies precede infection or are caused by immune activation of HGE deserves further study. | lld:pubmed |
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| pubmed-article:9650944 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9650944 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9650944 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9650944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9650944 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9650944 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:9650944 | pubmed:author | pubmed-author:ThomasJ AJA | lld:pubmed |
| pubmed-article:9650944 | pubmed:author | pubmed-author:WoodS NSN | lld:pubmed |
| pubmed-article:9650944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9650944 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:9650944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9650944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9650944 | pubmed:pagination | 1959-63 | lld:pubmed |
| pubmed-article:9650944 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9650944 | pubmed:meshHeading | pubmed-meshheading:9650944-... | lld:pubmed |
| pubmed-article:9650944 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9650944 | pubmed:articleTitle | Cytoplasmic, nuclear, and platelet autoantibodies in human granulocytic ehrlichiosis patients. | lld:pubmed |
| pubmed-article:9650944 | pubmed:affiliation | Wadsworth Center, New York State Department of Health, Albany 12201-2002, USA. wong@wadsworth.org | lld:pubmed |
| pubmed-article:9650944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9650944 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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