|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1998-9-28
|
|
pubmed:abstractText |
Serum samples from patients with confirmed human granulocytic ehrlichiosis (HGE) were tested for cytoplasmic, nuclear, and platelet autoantibodies and rheumatoid factor. The indirect fluorescence antinuclear antibody test on Hep-2 cells demonstrated antinuclear titers of > or = 40 and > or = 160 in 44 and 10%, respectively, of serum samples from HGE patients. Two patients (4%) had anticytoplasmic (mitochondrial and spindle apparatus) antibodies with a titer of 80 and two patients (4%) had anticytoplasmic (mitochondrial) antibodies with a titer of 160 or greater. Flow cytometry was used to demonstrate antiplatelet antibodies in 80% of first serum samples from HGE patients. Rheumatoid factor was not detected. Nuclear and cytoplasmic autoantibodies are a major cause of interference when the indirect fluorescence antibody test is used to detect fluorescence of morulae in Ehrlichia-infected equine neutrophils or HL-60 promyelocytes. Antiplatelet antibodies may contribute to the profound thrombocytopenia which is a characteristic laboratory feature during the acute phase of HGE infection. Whether autoantibodies precede infection or are caused by immune activation of HGE deserves further study.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-1140846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-1649021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-3891174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-3970049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-4140878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-7561199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-7611594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-7619983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8022040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8533312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8603945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8604172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8645839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8681291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8699065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8797272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8857006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8885863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-8967671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-9163287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-9276387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-9276390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-9278605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9650944-9554683
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0095-1137
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
36
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1959-63
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9650944-Agglutination,
pubmed-meshheading:9650944-Antibodies, Antinuclear,
pubmed-meshheading:9650944-Autoantibodies,
pubmed-meshheading:9650944-Blood Platelets,
pubmed-meshheading:9650944-Cytoplasm,
pubmed-meshheading:9650944-Ehrlichiosis,
pubmed-meshheading:9650944-Flow Cytometry,
pubmed-meshheading:9650944-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:9650944-Humans,
pubmed-meshheading:9650944-Latex,
pubmed-meshheading:9650944-Rheumatoid Factor,
pubmed-meshheading:9650944-Staining and Labeling
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Cytoplasmic, nuclear, and platelet autoantibodies in human granulocytic ehrlichiosis patients.
|
|
pubmed:affiliation |
Wadsworth Center, New York State Department of Health, Albany 12201-2002, USA. wong@wadsworth.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
