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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0008051,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0028754,
umls-concept:C0080194,
umls-concept:C0087111,
umls-concept:C0205359,
umls-concept:C0920350,
umls-concept:C1515655,
umls-concept:C1527148
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pubmed:issue |
2
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pubmed:dateCreated |
1998-10-22
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pubmed:abstractText |
The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at hatching. The birds were killed at 19-25 days of age. Treatment with anti-CD4 antibody completely prevented SAT development, while treatment with anti-CD8 antibody partially inhibited SAT. These results show the critical role of CD4+ T cells in the development of SAT in OS chickens, and indicate that CD8+ T cells are also involved in SAT pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0896-8411
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pubmed:author |
pubmed-author:CihalKK,
pubmed-author:HálaKK,
pubmed-author:Hoffmann-FezerGG,
pubmed-author:KaspersBB,
pubmed-author:LöschUU,
pubmed-author:MerkleHH,
pubmed-author:PlachýJJ,
pubmed-author:RüstEE,
pubmed-author:StangassingerMM,
pubmed-author:VainioOO,
pubmed-author:WickGG
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9650090-Age Factors,
pubmed-meshheading:9650090-Animals,
pubmed-meshheading:9650090-Antibodies, Monoclonal,
pubmed-meshheading:9650090-Antigens, CD4,
pubmed-meshheading:9650090-Antigens, CD8,
pubmed-meshheading:9650090-Autoantibodies,
pubmed-meshheading:9650090-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9650090-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9650090-Chickens,
pubmed-meshheading:9650090-Disease Models, Animal,
pubmed-meshheading:9650090-Immunoenzyme Techniques,
pubmed-meshheading:9650090-Inbreeding,
pubmed-meshheading:9650090-Mice,
pubmed-meshheading:9650090-Obesity,
pubmed-meshheading:9650090-Poultry Diseases,
pubmed-meshheading:9650090-Thyroglobulin,
pubmed-meshheading:9650090-Thyroid Gland,
pubmed-meshheading:9650090-Thyroiditis, Autoimmune
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pubmed:year |
1998
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pubmed:articleTitle |
Inhibition of the development of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by in vivo treatment with anti-CD4 or anti-CD8 antibodies.
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pubmed:affiliation |
Institute for Animal Physiology, University of Munich, Germany. cihak@t-online.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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