Linked Life Data

9648937

Source:http://linkedlifedata.com/resource/pubmed/id/9648937

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-7-10
pubmed:abstractText
The coitally induced gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) surge in the rabbit is preceded by an enhanced secretion of hypothalamic norepinephrine (NE). To investigate if adrenergic receptors are essential for the GnRH/LH surge, we administered a specific alpha1 receptor blocker, prazosin, into either the arcuate nucleus-median eminence (AME) or the third cerebroventricle (3rd V) of tethered, freely moving intact female rabbits via push-pull perfusion (PPP). Dual cannulae for PPP and drug infusion were placed stereotaxically either into the AME or AME and 3rd V of each rabbit after insertion of a permanent femoral venous catheter for serial blood sampling. During an experiment, continuous PPP samples and 10-min intermittent blood samples were collected for 5-6 hr. Females received either prazosin or control medium (artificial cerebrospinal fluid into an AME or saline into a 3rd V cannula) for 4 hr, beginning 1 hr before coitus. Intraventricular infusion of prazosin significantly (P < 0.05) suppressed both the postcoital GnRH and the LH surges. Administration of prazosin into the AME also attenuated the magnitude of the postcoital GnRH surge (P < 0.05) whereas postcoital LH values were not decreased below that of the control group (P > 0.05). The results suggest that alpha1 receptors are physiologically active in the initiation of the postcoital GnRH release. These findings, along with our earlier report of enhanced postcoital NE secretion, reinforce the hypothesis that NE plays an essential role in the preovulatory GnRH/LH surge in rabbits.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
218
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
204-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Attenuation of gonadotropin-releasing hormone reflex to coitus by alpha1-adrenergic receptor blockade in the rabbit.
pubmed:affiliation
Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.