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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-7-9
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pubmed:abstractText |
Several members of the Ly-49 receptor family inhibit NK cell-mediated lysis of targets expressing appropriate MHC class I molecules. Ly-49D and Ly-49H, two Ly-49 molecules that lack immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, associate with mouse DAP12, a molecule that possesses an immunoreceptor tyrosine-based activation motif (ITAM). Cotransfection of either Ly-49D or Ly-49H with DAP12 induces surface expression of both Ly-49 and DAP12. The Ly-49/DAP12 complex was coimmunoprecipitated from the transfected cells, demonstrating a physical association of DAP12 with Ly-49D or Ly-49H in the plasma membrane. Stimulation of transfectants with Abs recognizing either Ly-49D or Ly-49H results in cellular activation, as assessed by induction of tyrosine phosphorylation of multiple cellular substrates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Amino Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like,
http://linkedlifedata.com/resource/pubmed/chemical/TYROBP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/tyrosine receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-10
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9647200-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9647200-Animals,
pubmed-meshheading:9647200-Antigens, Ly,
pubmed-meshheading:9647200-Antigens, Surface,
pubmed-meshheading:9647200-Interleukin-2,
pubmed-meshheading:9647200-Killer Cells, Natural,
pubmed-meshheading:9647200-Lectins, C-Type,
pubmed-meshheading:9647200-Lymphocyte Activation,
pubmed-meshheading:9647200-Membrane Glycoproteins,
pubmed-meshheading:9647200-Membrane Proteins,
pubmed-meshheading:9647200-Mice,
pubmed-meshheading:9647200-Receptors, Amino Acid,
pubmed-meshheading:9647200-Receptors, Immunologic,
pubmed-meshheading:9647200-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:9647200-Transcription, Genetic,
pubmed-meshheading:9647200-Transfection,
pubmed-meshheading:9647200-Tyrosine
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pubmed:year |
1998
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pubmed:articleTitle |
Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors.
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pubmed:affiliation |
DNAX Research Institute, Palo Alto, CA 94304, USA. ksmith@dnax.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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