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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1976-12-1
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pubmed:abstractText |
Intragastric pressure was measured in dogs with gastric fistulas by using a flaccid balloon containing 500 ml of water. Intravenous infusion of cholecystokinin (20% pure), the carboxyl-terminal octapeptide of cholecystokinin, secretin, and vasoactive intestinal peptide produced dose-related decreases in intragastric pressure with maximal decreases of 40% or more. Glucagon and gastric inhibitory peptide produced smaller decreases in intragastric pressure. Motilin caused a dose-related increase in intragastric pressure that lasted only about 7 min despite continuing infusion of the peptide. The half-dose of cholecystokinin or of octapeptide of cholecystokinin for pancreatic protein secretion and the half-dose of secretin for pancreatic bicarbonate secretion each produced significant inhibition of intragastric pressure, suggesting that these hormones play a physiological reole in regulating gastric pressure.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholecystokinin,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Secretin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
766-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:964568-Animals,
pubmed-meshheading:964568-Cholecystokinin,
pubmed-meshheading:964568-Dogs,
pubmed-meshheading:964568-Dose-Response Relationship, Drug,
pubmed-meshheading:964568-Gastrointestinal Hormones,
pubmed-meshheading:964568-Gastrointestinal Motility,
pubmed-meshheading:964568-Glucagon,
pubmed-meshheading:964568-Manometry,
pubmed-meshheading:964568-Peptides,
pubmed-meshheading:964568-Pressure,
pubmed-meshheading:964568-Secretin,
pubmed-meshheading:964568-Stomach
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pubmed:year |
1976
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pubmed:articleTitle |
Effect of intestinal hormones and peptides on intragastric pressure in dogs.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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