Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-7-7
pubmed:abstractText
52 patients with early rheumatoid arthritis (RA) were followed with regular measurements of bone mineral density (BMD) and serum markers of type I collagen metabolism in order to determine whether they develop osteoporosis during the first two years of the disease course and if the changes in type I collagen metabolites reflect the alterations in BMD. The mean percentage BMD change over the first year of follow-up was -0.91 for lumbar spine (LS) and -0.76 for femoral neck (FN); the corresponding figures from 0 to 24 months was -1.3 and -0.8, respectively. During the follow-up, only five patients developed osteoporosis by the Z-score definition (<-1). If defined by T-score (<-2.5) none of the patients developed osteoporosis. The BMD change correlated neither with the clinical parameters of disease activity nor with the markers of collagen metabolism. However, the BMD change in FN was associated with the cumulative corticosteroid dose (r=-0.31, p <0.05, 95% CI -0.54 to -0.04). Reasons for the lack of accelerated bone loss in our series are open to various interpretations. This series was community based and most of the patients had mild RA. The patients were also actively treated and their physical function did not deteriorate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9742
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
188-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9645413-Adult, pubmed-meshheading:9645413-Aged, pubmed-meshheading:9645413-Arthritis, Rheumatoid, pubmed-meshheading:9645413-Bone Density, pubmed-meshheading:9645413-Collagen, pubmed-meshheading:9645413-Collagen Type I, pubmed-meshheading:9645413-Community Health Services, pubmed-meshheading:9645413-Female, pubmed-meshheading:9645413-Femur Neck, pubmed-meshheading:9645413-Finland, pubmed-meshheading:9645413-Follow-Up Studies, pubmed-meshheading:9645413-Humans, pubmed-meshheading:9645413-Incidence, pubmed-meshheading:9645413-Lumbar Vertebrae, pubmed-meshheading:9645413-Male, pubmed-meshheading:9645413-Middle Aged, pubmed-meshheading:9645413-Osteoporosis, pubmed-meshheading:9645413-Peptide Fragments, pubmed-meshheading:9645413-Peptides, pubmed-meshheading:9645413-Procollagen
pubmed:year
1998
pubmed:articleTitle
Low incidence of osteoporosis in a two year follow-up of early community based patients with rheumatoid arthritis.
pubmed:affiliation
Division of Rheumatology, University of Oulu, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't