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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-8-28
|
| pubmed:abstractText |
The lipoprotein lipase (LPL) promoter -93T/G transition has previously been reported as having a triglyceride (Tg)-lowering effect, whereas the D9N variant has been shown to have a Tg-raising effect. These two variants were studied in 66 healthy subjects of Hispanic and 42 subjects of African-American origin, who had participated in a study of postprandial lipemia. While the allele frequency of the -93G was significantly different in the Hispanics and African Americans (0.09: 95% CI 0.04-0.13 and 0.28: 95% CI 0.19-0.38; P=0.0001, respectively), the N9 allele frequency was not different (0.06: 95% CI 0.02-0.1 and 0.05: 95% CI 0.002-0.093, respectively). Linkage disequilibrium between the -93T/G and D9N was highly significant in Hispanics (delta=0.67. P=0.0001), compared to delta=0.09 (NS) in African-Americans. In the combined group, compared to individuals with the common genotype (TT/DD; n=71) with fasting plasma Tg of 1.34 (+/-4.5% SEM) mmol/l, carriers of the G/D haplotype (TG/DD + GG/DD; n=25) had significantly lower plasma Tg levels of 1.08 (+/-10% SEM) mmol/l (P < 0.02). After the fat meal, compared to individuals with neither mutation, TT/DD, the effect of the G/D haplotype was to reduce significantly postprandial Tg (P < 0.036). Retinyl palmitate concentration at 5 hrs was significantly lower in G/D carriers than TT/DD individuals (P < 0.05). The lipid-raising effect of the N9 allele in carriers of the -93G (TG/DN + GG/DN) and effect on postprandial Tg clearance was not significant in this group. Thus carriers of the G/D haplotype have lower fasting plasma Tg and reduced alimentary lipemia. This allele may be associated with reduced risk of coronary artery disease.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-2275
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1189-96
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9643350-Adult,
pubmed-meshheading:9643350-African Americans,
pubmed-meshheading:9643350-African Continental Ancestry Group,
pubmed-meshheading:9643350-Aged,
pubmed-meshheading:9643350-Fasting,
pubmed-meshheading:9643350-Female,
pubmed-meshheading:9643350-Genotype,
pubmed-meshheading:9643350-Guanine,
pubmed-meshheading:9643350-Haplotypes,
pubmed-meshheading:9643350-Hispanic Americans,
pubmed-meshheading:9643350-Humans,
pubmed-meshheading:9643350-Linkage Disequilibrium,
pubmed-meshheading:9643350-Lipoprotein Lipase,
pubmed-meshheading:9643350-Male,
pubmed-meshheading:9643350-Metabolic Clearance Rate,
pubmed-meshheading:9643350-Middle Aged,
pubmed-meshheading:9643350-New York City,
pubmed-meshheading:9643350-Point Mutation,
pubmed-meshheading:9643350-Postprandial Period,
pubmed-meshheading:9643350-Promoter Regions, Genetic,
pubmed-meshheading:9643350-Thymine,
pubmed-meshheading:9643350-Triglycerides
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
LPL promoter -93T/G transition influences fasting and postprandial plasma triglycerides response in African-Americans and Hispanics.
|
| pubmed:affiliation |
Centre for Genetics of Cardiovascular Disorders, University College London Medical School, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|