| pubmed-article:9640248 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9640248 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:9640248 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:9640248 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:9640248 | lifeskim:mentions | umls-concept:C1519623 | lld:lifeskim |
| pubmed-article:9640248 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9640248 | pubmed:dateCreated | 1998-7-7 | lld:pubmed |
| pubmed-article:9640248 | pubmed:abstractText | Signalling through the CD2 molecule was shown previously to employ similar signalling molecules as the T-cell receptor (TCR). Here, we show that CD2-mediated signalling is strongly influenced by the expressed transmembrane region of the employed signal-transducing molecule. We used TCR-negative cells expressing chimeric fusion proteins that consist of human interleukin-2 (IL-2) receptor alpha-chain-derived sequences (hCD25) fused to mouse-specific zeta-chain segments (hCD25-zeta). One set of TCR-negative cell lines expressed the hCD25-derived extracellular part fused to mouse-specific transmembrane and cytoplasmic zeta-protein sequences ('TZZ'). The second type of cell lines expressed the hCD25-derived extracellular and transmembrane portions fused to the mouse-specific zeta-chain cytoplasmic segment ('TTZ'). After cross-linking the hCD25-zeta molecules with specific monoclonal antibodies (mAb), all TCR-negative cell lines produced similar amounts of IL-2. Cross-linking with stimulating pairs of CD2-specific mAb, however, led to IL-2 production only in cell lines expressing the zeta-chain-specific transmembrane segment. Co-cross-linking of CD25 and CD2 molecules resulted in an effective stimulation of both TZZ- and TTZ-expressing cell lines. Moreover, TTZ- and TZZ-expressing cell lines differed in their pattern of tyrosine-phosphorylated proteins after stimulation with hCD25-specific mAb. Thus, although CD2 and TCR molecules share signalling components and pathways, the fine tuning of CD2 co-receptor function appears to be regulated in part by transmembrane regions of signal-transducing molecules like the TCR-associated zeta-chain. | lld:pubmed |
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| pubmed-article:9640248 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9640248 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9640248 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9640248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9640248 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9640248 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9640248 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:9640248 | pubmed:author | pubmed-author:FleischerBB | lld:pubmed |
| pubmed-article:9640248 | pubmed:author | pubmed-author:EhrlichSS | lld:pubmed |
| pubmed-article:9640248 | pubmed:author | pubmed-author:Von BoninAA | lld:pubmed |
| pubmed-article:9640248 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9640248 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:9640248 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9640248 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9640248 | pubmed:pagination | 376-82 | lld:pubmed |
| pubmed-article:9640248 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
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| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:meshHeading | pubmed-meshheading:9640248-... | lld:pubmed |
| pubmed-article:9640248 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9640248 | pubmed:articleTitle | The transmembrane region of CD2-associated signal-transducing proteins is crucial for the outcome of CD2-mediated T-cell activation. | lld:pubmed |
| pubmed-article:9640248 | pubmed:affiliation | Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany. | lld:pubmed |
| pubmed-article:9640248 | pubmed:publicationType | Journal Article | lld:pubmed |
