Linked Life Data

9640121

Source:http://linkedlifedata.com/resource/pubmed/id/9640121

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-7-2
pubmed:abstractText
Forty healthy patients undergoing orthopaedic surgery were randomly allocated to receive an initial blood propofol target concentration of either 4 micrograms.ml-1 or 6 micrograms.ml-1 for induction of anaesthesia with a 'Diprifusor' target controlled infusion system for propofol, and analgesic supplementation with either nitrous oxide 67% in oxygen or alfentanil 15-20 micrograms.kg-1.h-1. Anaesthesia was induced within 3 min in 80% and 95% of patients with propofol target concentrations of 4 micrograms.ml-1 and 6 micrograms.ml-1, respectively. The frequency of discomfort on infusion was similar for both target concentrations. During maintenance, supplementary doses of alfentanil were required to provide adequate surgical conditions in approximately half of the patients receiving nitrous oxide. There was no statistically significant difference between the target concentration [mean (SD)] of propofol for total intravenous anaesthesia [5.1 (2.0) micrograms.ml-1] compared with a technique using nitrous oxide [4.6 (1.2) micrograms.ml-1] supplemented as needed with small doses of alfentanil.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0003-2409
pubmed:author
pubmed:issnType
Print
pubmed:volume
53 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Influence of analgesic supplementation on the target propofol concentrations for anaesthesia with 'Diprifusor' TCI.
pubmed:affiliation
Department of Anaesthesia, University Hospital Centre, Hôpital Bichat, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial