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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-9-24
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pubmed:abstractText |
T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based activation motifs and tyrosine kinases, inhibitory signals are delivered by tyrosine phosphatases. Unresponsiveness is also induced by modulation of signaling components of the T cell receptor complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0952-7915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9638368-Animals,
pubmed-meshheading:9638368-Antigens, CD,
pubmed-meshheading:9638368-Antigens, Differentiation,
pubmed-meshheading:9638368-CTLA-4 Antigen,
pubmed-meshheading:9638368-Consensus Sequence,
pubmed-meshheading:9638368-Cytokines,
pubmed-meshheading:9638368-Endocytosis,
pubmed-meshheading:9638368-Gene Expression Regulation,
pubmed-meshheading:9638368-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:9638368-Humans,
pubmed-meshheading:9638368-Immunoconjugates,
pubmed-meshheading:9638368-Killer Cells, Natural,
pubmed-meshheading:9638368-Lymphocyte Activation,
pubmed-meshheading:9638368-Lysosomes,
pubmed-meshheading:9638368-Models, Immunological,
pubmed-meshheading:9638368-Oxidation-Reduction,
pubmed-meshheading:9638368-Phosphorylation,
pubmed-meshheading:9638368-Protein Processing, Post-Translational,
pubmed-meshheading:9638368-Protein Tyrosine Phosphatases,
pubmed-meshheading:9638368-Receptors, Antigen, T-Cell,
pubmed-meshheading:9638368-Receptors, Cytokine,
pubmed-meshheading:9638368-Receptors, Immunologic,
pubmed-meshheading:9638368-Receptors, KIR,
pubmed-meshheading:9638368-T-Lymphocytes
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pubmed:year |
1998
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pubmed:articleTitle |
Negative regulation of T cell activation.
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pubmed:affiliation |
Department of Molecular Genetics, Chiba University Graduate School of Medicine, Japan. saito@med.m.chiba-u.ac.jp
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pubmed:publicationType |
Journal Article,
Review
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