|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1998-7-20
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
IL-16 has been reported as a modulator of T cell activation and was shown to function as chemoattractant factor. The chemotactic activity of IL-16 depends on the expression of CD4 on the surface of target cells, but the intracellular signaling pathways are only now being deciphered. This report describes IL-16 as an additional activator of the stress-activated protein kinase (SAPK) pathway in CD4+ macrophages. Treatment of these cells with recombinant expressed IL-16 leads to the phosphorylation of SEK-1, resulting in activation of the SAPKs p46 and p54. IL-16 stimulation also leads to the phosphorylation of c-Jun and p38 MAPK (mitogen-activated protein kinase), without inducing MAPK-family members ERK-1 and ERK-2. Interestingly, the IL-16-mediated activation of SAPKs and p38 MAPK in macrophages alone induces no detectable apoptotic cell death. These observations suggest specific regulatory functions of IL-16 distinct from the proinflammatory cytokines TNF-alpha and IL-1beta.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-16,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
160
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5874-9
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:9637499-Animals,
pubmed-meshheading:9637499-Antigens, CD4,
pubmed-meshheading:9637499-Apoptosis,
pubmed-meshheading:9637499-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9637499-Cells, Cultured,
pubmed-meshheading:9637499-Cloning, Molecular,
pubmed-meshheading:9637499-Enzyme Activation,
pubmed-meshheading:9637499-Humans,
pubmed-meshheading:9637499-Interleukin-16,
pubmed-meshheading:9637499-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9637499-MAP Kinase Kinase 4,
pubmed-meshheading:9637499-Macrophages,
pubmed-meshheading:9637499-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:9637499-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:9637499-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:9637499-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9637499-Molecular Sequence Data,
pubmed-meshheading:9637499-Phosphorylation,
pubmed-meshheading:9637499-Protein Kinases,
pubmed-meshheading:9637499-Signal Transduction,
pubmed-meshheading:9637499-Spodoptera,
pubmed-meshheading:9637499-Tyrosine,
pubmed-meshheading:9637499-p38 Mitogen-Activated Protein Kinases
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
IL-16 activates the SAPK signaling pathway in CD4+ macrophages.
|
|
pubmed:affiliation |
Department of Immunobiology, Fraunhofer Institute for Toxicology and Molecular Biology, Hannover, Germany. krautwald@ita.fhg.de
|
|
pubmed:publicationType |
Journal Article
|
