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rdf:type |
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lifeskim:mentions |
umls-concept:C0003191,
umls-concept:C0014834,
umls-concept:C0039194,
umls-concept:C0069460,
umls-concept:C0205263,
umls-concept:C0871261,
umls-concept:C1415782,
umls-concept:C1555707,
umls-concept:C1704632,
umls-concept:C1705851,
umls-concept:C1706817,
umls-concept:C2752151,
umls-concept:C2828366,
umls-concept:C2911692
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pubmed:issue |
9-10
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|
pubmed:dateCreated |
1998-9-17
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pubmed:abstractText |
Oral administration of E. coli extract OM-89 is used in treating RA. It has been shown that immune reactivity to heat-shock proteins (hsp) is involved in immunomodulation of arthritis. We evaluated the postulated presence and immunogenicity of hsp's in OM-89. The effects of OM-89 in experimental arthritis were analyzed. Proliferative T cell responses to bacterial hsp60 and hsp70 were found in rats immunized with OM-89. And conversely, immunization with hsp antigens induced OM-89-specific T cell responses. Hsp70 (DnaK) was found to be a major immunogenic constituent of OM-89. Parenteral immunization with OM-89 reduces resistance to adjuvant arthritis (AA), whereas oral administration protects against AA. Given the arthritis inhibitory effect of oral OM-89 in AA our findings suggest peripheral tolerance induced by hsp-specific regulatory T cells as a mode of action for OM-89 as an arthritis suppressive oral drug.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0192-0561
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
565-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9637355-Animals,
pubmed-meshheading:9637355-Antigens, Bacterial,
pubmed-meshheading:9637355-Antirheumatic Agents,
pubmed-meshheading:9637355-Chaperonin 60,
pubmed-meshheading:9637355-Escherichia coli,
pubmed-meshheading:9637355-HSP70 Heat-Shock Proteins,
pubmed-meshheading:9637355-Immune Tolerance,
pubmed-meshheading:9637355-Immunosuppressive Agents,
pubmed-meshheading:9637355-Mycobacterium,
pubmed-meshheading:9637355-Rats,
pubmed-meshheading:9637355-Rats, Inbred Lew,
pubmed-meshheading:9637355-T-Lymphocytes
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pubmed:articleTitle |
Antirheumatic E. coli extract OM-89 induces T cell responses to HSP60 and 70.
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pubmed:affiliation |
Institute for Infectious Diseases and Immunology, Utrecht University, The Netherlands.
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pubmed:publicationType |
Journal Article
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