Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1998-8-6
pubmed:abstractText
Differentiation and function of pancreatic beta cells are regulated by a variety of hormones and growth factors, including nerve growth factor (NGF). Whether this is an endocrine or autocrine/paracrine role for NGF is not known. We demonstrate that NGF is produced and secreted by adult rat pancreatic beta cells. NGF secretion is increased in response to elevated glucose or potassium, but decreased in response to dibutyryl cAMP. Moreover, steady-state levels of NGF mRNA are down-regulated by dibutyryl cAMP, which is opposite to the effect of cAMP on insulin release. NGF-stimulated changes in morphology and function are mediated by high-affinity Trk A receptors in other mammalian cells. Trk A receptors are present in beta cells and steady-state levels of Trk A mRNA are modulated by NGF and dibutyryl cAMP. Taken together, these findings suggest endocrine and autocrine roles for pancreatic beta-cell NGF, which, in turn, could be related to the pathogenesis of diabetes mellitus where serum NGF levels are diminished.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-1312719, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-1337933, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-1524827, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-1850821, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-2032290, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-2142224, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-2375241, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-2458427, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-2987855, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-3301324, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-3532145, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-6092126, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-6292032, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-7543930, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-7692896, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-7713882, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-7789343, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-7835308, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-8194458, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-8516328, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-8694907, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-8847739, http://linkedlifedata.com/resource/pubmed/commentcorrection/9636228-8996659
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7784-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Pancreatic beta cells synthesize and secrete nerve growth factor.
pubmed:affiliation
Department of Biophysics, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México DF 04510 Mexico.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't