Linked Life Data

9636081

Source:http://linkedlifedata.com/resource/pubmed/id/9636081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1998-8-27
pubmed:abstractText
Mammalian gonadal development and sexual differentiation are complex processes that require the coordinated expression of a specific set of genes in a strict spatiotemporal manner. Although some of these genes have been identified, the molecular pathways, including transcription factors, that are critical for the early events of lineage commitment and sexual dimorphism, remain poorly understood. GATA-4, a member of the GATA family of transcription factors, is present in the gonads and may be a regulator of gonadal gene expression. We have analyzed the ontogeny of gonadal GATA-4 expression by immunohistochemistry. GATA-4 protein was detected as early as embryonic day 11.5 in the primitive gonads of both XX and XY mouse embryos. In both sexes, GATA-4 specifically marked the developing somatic cell lineages (Sertoli in testis and granulosa in ovary) but not primordial germ cells. Interestingly, abundant GATA-4 expression was maintained in Sertoli cells throughout embryonic development but was markedly down-regulated shortly after the histological differentiation of the ovary on embryonic day 13.5. This pattern of expression suggested that GATA-4 might be involved in early gonadal development and possibly sexual dimorphism. Consistent with this hypothesis, we found that the Müllerian inhibiting substance promoter which harbors a conserved GATA element is a downstream target for GATA-4. Thus, transcription factor GATA-4 may be a new factor in the cascade of regulators that control gonadal development and sex differentiation in mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2665-75
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9636081-Animals, pubmed-meshheading:9636081-Anti-Mullerian Hormone, pubmed-meshheading:9636081-Binding Sites, pubmed-meshheading:9636081-DNA-Binding Proteins, pubmed-meshheading:9636081-Embryo, Mammalian, pubmed-meshheading:9636081-Embryonic and Fetal Development, pubmed-meshheading:9636081-Erythroid-Specific DNA-Binding Factors, pubmed-meshheading:9636081-Female, pubmed-meshheading:9636081-GATA4 Transcription Factor, pubmed-meshheading:9636081-Gene Expression Regulation, Developmental, pubmed-meshheading:9636081-Glycoproteins, pubmed-meshheading:9636081-Gonads, pubmed-meshheading:9636081-Growth Inhibitors, pubmed-meshheading:9636081-Immunohistochemistry, pubmed-meshheading:9636081-Male, pubmed-meshheading:9636081-Mice, pubmed-meshheading:9636081-Mice, Inbred Strains, pubmed-meshheading:9636081-Ovary, pubmed-meshheading:9636081-Promoter Regions, Genetic, pubmed-meshheading:9636081-Sertoli Cells, pubmed-meshheading:9636081-Sex Differentiation, pubmed-meshheading:9636081-Testicular Hormones, pubmed-meshheading:9636081-Testis, pubmed-meshheading:9636081-Transcription Factors
pubmed:year
1998
pubmed:articleTitle
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.
pubmed:affiliation
Laboratoire de Développement et différenciation cardiaques, Institut de recherches cliniques de Montréal and Département de pharmacologie, Université de Montréal, Montréal, Québec, Canada H2W 1R7.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't