Linked Life Data

9636075

Source:http://linkedlifedata.com/resource/pubmed/id/9636075

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1998-8-27
pubmed:databankReference
pubmed:abstractText
The vertebrate forebrain is formed at the rostral end of the neural plate under the regulation of local and specific signals emanating from both the endomesoderm and neuroectoderm. The development of the rostral and ventral forebrain in particular was difficult to study, mainly because no specific markers are available to date. Here, we report the identification of Vax1, a novel homeobox-containing gene identified in mouse, Xenopus and human. It is closely related to members of the Not and Emx gene families, all of which are required for the formation of structures where they are expressed. In mouse and Xenopus, Vax1 expression first occurs in the rostral neural plate, in the medial anterior neural ridge and adjacent ectoderm. Later, at midgestation in the mouse and tadpole stage in Xenopus, the expression remains confined in the derivatives of this territory which differentiate into rostromedial olfactory placode, optic nerve and disc, and anterior ventral forebrain. Together, these observations suggest that Vax1 could have an early evolutionary origin and could participate in the specification and formation of the rostral and ventral forebrain in vertebrates. Comparison of the limits of the expression territory of Vax1 with that of Dlx1, Pax6 and Emx1 indicates that the corticostriatal ridge is a complex structure with distinct identifiable genetic compartments. Besides, the study of Vax1 expression in Pax6-deficient homozygous brains indicates that its regulation is independent of Pax6, although the expression patterns of these two genes appear complementary in wild-type animals. Vax1 chromosomal location is mapped at the distal end of the mouse chromosome 19, linked with that of Emx2. These two genes may have arisen by tandem duplication. The Vax1 gene is thus an interesting new tool to study the rostral ventral forebrain patterning, morphogenesis and evolution as well as the terminal differentiation of the forebrain in mouse and Xenopus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2599-610
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9636075-Amino Acid Sequence, pubmed-meshheading:9636075-Animals, pubmed-meshheading:9636075-Brain, pubmed-meshheading:9636075-Cell Differentiation, pubmed-meshheading:9636075-Chromosome Mapping, pubmed-meshheading:9636075-Cloning, Molecular, pubmed-meshheading:9636075-DNA-Binding Proteins, pubmed-meshheading:9636075-Eye Proteins, pubmed-meshheading:9636075-Gene Expression Regulation, Developmental, pubmed-meshheading:9636075-Genes, Homeobox, pubmed-meshheading:9636075-Homeodomain Proteins, pubmed-meshheading:9636075-In Situ Hybridization, pubmed-meshheading:9636075-Mice, pubmed-meshheading:9636075-Molecular Sequence Data, pubmed-meshheading:9636075-Neuropeptides, pubmed-meshheading:9636075-Paired Box Transcription Factors, pubmed-meshheading:9636075-RNA, Messenger, pubmed-meshheading:9636075-Repressor Proteins, pubmed-meshheading:9636075-Sequence Analysis, DNA, pubmed-meshheading:9636075-Sequence Homology, Amino Acid, pubmed-meshheading:9636075-Transcription Factors, pubmed-meshheading:9636075-Xenopus, pubmed-meshheading:9636075-Xenopus Proteins
pubmed:year
1998
pubmed:articleTitle
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain.
pubmed:affiliation
Max Planck Institut for Biophysical Chemistry, Department of Molecular and Cell Biology, Am Fassberg 11, Germany.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't