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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-7-9
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pubmed:databankReference |
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pubmed:abstractText |
The rapid engulfment (phagocytosis) of cells undergoing programmed cell death (apoptosis) is a fundamental biological process that is not well understood. Here we report the cloning and functional characterization of ced-6, a gene specifically required for the engulfment of apoptotic cells in the nematode C. elegans. The CED-6 protein contains a phosphotyrosine binding domain at its N terminus and a proline/serine-rich region in its C-terminal half. Genetic mosaic analysis demonstrates that ced-6 acts within engulfing cells. We also show that ced-6 can promote the engulfment of cells at both early and late stages of apoptosis. Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
961-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9635426-Amino Acid Sequence,
pubmed-meshheading:9635426-Animals,
pubmed-meshheading:9635426-Animals, Genetically Modified,
pubmed-meshheading:9635426-Apoptosis,
pubmed-meshheading:9635426-Base Sequence,
pubmed-meshheading:9635426-Caenorhabditis elegans,
pubmed-meshheading:9635426-Caenorhabditis elegans Proteins,
pubmed-meshheading:9635426-Cloning, Molecular,
pubmed-meshheading:9635426-Genes, Helminth,
pubmed-meshheading:9635426-Molecular Sequence Data,
pubmed-meshheading:9635426-Mosaicism,
pubmed-meshheading:9635426-Mutation,
pubmed-meshheading:9635426-Phagocytosis,
pubmed-meshheading:9635426-Phosphoproteins,
pubmed-meshheading:9635426-Phosphotyrosine,
pubmed-meshheading:9635426-RNA, Helminth,
pubmed-meshheading:9635426-RNA, Messenger,
pubmed-meshheading:9635426-Sequence Homology, Amino Acid,
pubmed-meshheading:9635426-Signal Transduction,
pubmed-meshheading:9635426-src Homology Domains
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pubmed:year |
1998
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pubmed:articleTitle |
Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.
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pubmed:affiliation |
Cold Spring Harbor Laboratory, New York 11724, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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